Disease ⇒ Caries {40000204}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Caries

Details
Initialisation date:	[ ]
Other Terms:	[ ]

Meta Information
MedDra ID:	10012318
MedDra Level:	pt
ICD:	[ ]
Category:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

[ ]

Shared Reference Notes

[1.1]
- Some members of the genera #Porphyromonas, #Prevotella, and #Tannerella are well-known pathogens of the oral cavity, where they can notably cause #Periodontal disease and dental caries.
[1.2]
- #Candida-infected individuals had 2.3 times more dental caries than those without #Candida in their oral cavity
[1.3]
- #3,3′-Diindolylmethane (DIM), in mitigating the pathogenicity of the oral biofilm inhabiting bacterium #Streptococcus mutans, a bacterium that is considered to be a principal etiological agent in dental caries. - DIM was able to attenuate S. mutans biofilm formation by 92%. - treatment with DIM lowered extracellular polymeric substance (EPS) production and decreased its durability significantly under acidic conditions.
[1.4] [#Streptococcus mutans]
- #Lactobacilli inhibit the proliferation of S. mutans, a bacterium that causes dental caries
[1.5] [#Candida albicans, #Fusobacterium nucleatum, #Streptococcus oralis]
- The ability of C. albicans to form alliances with F. nucleatum, circumventing host defenses, and its interaction with #Streptococcus mutans, or S. oralis to exacerbate oral candidiasis or dental caries
[1.6]
- #Nitrate also altered oral microbiome metabolism, causing an increase in pH levels, which is beneficial to limit caries development.
- acute and chronic #Nitrate exposure decreased caries-associated #Veillonella and #Streptococcus decreased .

References Notes

[ ]

↥ Microbiota

‐ Acinetobacter Supragingival plaque Human [1.7]
‐ Actinomyces graevenitzii Saliva Human [1.8]
‐ Actinomyces Dental plaque Human [1.9]
‐ Actinomyces Supragingival plaque Human [1.7]
‐ Alloprevotella Plaque Human [1.10]
‐ Alloprevotella Saliva Human [1.11]
‐ Anaeroglobus geminatus Supragingival plaque Human [1.12]
‐ Atopobium rimae Supragingival plaque Human [1.12]
‐ Atopobium Saliva Human [1.11]
‐ Atopobium Supragingival plaque Human [1.13]
‐ Bacteroides thetaiotaomicron Saliva Human [1.14]
‐ Bergeyella Supragingival plaque Human [1.12]
‐ Bifidobacterium dentium Saliva Human [1.15]
‐ Bifidobacterium dentium Supragingival plaque Human [1.12]
‐ Burkholderiaceae Supragingival plaque Human [1.12]
‐ Campylobacter Plaque Human [1.16]
‐ Candida albicans Supragingival plaque Human [1.17]
‐ Candida dubliniensis Supragingival plaque Human [1.18]
‐ Candida sake Supragingival plaque Human [1.19]
‐ Capnocytophaga Plaque Human [1.16]
‐ Capnocytophaga Saliva Human [1.20]
‐ Comamonas testosteroni Supragingival plaque Human [1.12]
‐ Comamonas Saliva Human [1.21]
‐ Cryptobacterium curtum Supragingival plaque Human [1.12]
‐ Cryptococcus neoformans Supragingival plaque Human [1.19]
‐ Dialister invisus Supragingival plaque Human [1.12]
‐ Dialister pneumosintes Biofilm sample Human [1.22]
‐ Dolosigranulum Saliva Human [1.11]
‐ Dolosigranulum Supragingival plaque Human [1.7]
‐ Eubacterium infirmum Supragingival plaque Human [1.12]
‐ Granulicatella elegans Plaque Human [1.10]
‐ Granulicatella Dental plaque Human [1.9]
‐ Haemophilus haemolyticus Plaque Human [1.23]
‐ Haemophilus Plaque Human [1.10]
‐ Haemophilus Supragingival plaque Human [1.24]
‐ Kingella oralis Plaque Human [1.23]
‐ Lachnospiraceae Supragingival plaque Human [1.12]
‐ Lactobacillus casei Supragingival plaque Human [1.12]
‐ Lactobacillus crispatus Dental plaque Human [1.25]
‐ Lactobacillus fermentum Dental plaque Human [1.25]
‐ Lactobacillus gasseri Supragingival plaque Human [1.12]
‐ Lactobacillus parafarraginis Supragingival plaque Human [1.12]
‐ Lactobacillus salivarius Dental plaque Human [1.26]
‐ Lactobacillus salivarius Saliva Human [1.15]
‐ Lactobacillus salivarius Supragingival plaque Human [1.12]
‐ Lactobacillus vaginalis Supragingival plaque Human [1.12]
‐ Lactobacillus Plaque Human [1.16]
‐ Lactobacillus Saliva Human [1.27]
‐ Lautropia Saliva Human [1.11]
‐ Leptotrichia wadei Dental plaque Human [1.26]
‐ Leptotrichia Saliva Human [1.20]
‐ Megasphaera Saliva Human [1.11]
‐ Microdochium Supragingival plaque Human [1.17]
‐ Mitsuokella Supragingival plaque Human [1.12]
‐ Mogibacterium vescum Supragingival plaque Human [1.12]
‐ Moryella Supragingival plaque Human [1.12]
‐ Nigrospora oryzae Supragingival plaque Human [1.17]
‐ Olsenella profusa Dental plaque Human [1.25]
‐ Olsenella profusa Supragingival plaque Human [1.12]
‐ Oribacterium Supragingival plaque Human [1.12]
‐ Parascardovia denticolens Dental plaque Human [1.26]
‐ Parascardovia denticolens Saliva Human [1.15]
‐ Parascardovia denticolens Supragingival plaque Human [1.12]
‐ Peptostreptococcaceae Biofilm sample Human [1.22]
‐ Porphyromonas catoniae Biofilm sample Human [1.22]
‐ Porphyromonas Saliva Human [1.20]
‐ Prevotella denticola Saliva Human [1.28]
‐ Prevotella histicola Plaque Human [1.23]
‐ Prevotella loescheii Plaque Human [1.23]
‐ Prevotella melaninogenica Plaque Human [1.10]
‐ Prevotella multisaccharivorax Dental plaque Human [1.25]
‐ Prevotella multisaccharivorax Supragingival plaque Human [1.12]
‐ Prevotella oralis Supragingival plaque Human [1.12]
‐ Prevotella oris Saliva Human [1.28]
‐ prevotella salivae Saliva Human [1.8]
‐ prevotella salivae Supragingival plaque Human [1.12]
‐ Prevotella Biofilm sample Human [1.22]
‐ Prevotella Saliva Human [1.20]
‐ Prevotella Supragingival plaque Human [1.7]
‐ Propionibacterium acidifaciens Dental plaque Human [1.25]
‐ Propionibacterium acidifaciens Supragingival plaque Human [1.12]
‐ Pseudomonas pseudoalcaligenes Supragingival plaque Human [1.12]
‐ Pseudomonas Supragingival plaque Human [1.7]
‐ Pseudoramibacter alactolyticus Supragingival plaque Human [1.12]
‐ Rothia denticariosa Saliva Human [1.8]
‐ Rothia mucilaginosa Saliva Human [1.14]
‐ Scardovia wiggsiae Dental plaque Human [1.26]
‐ Scardovia wiggsiae Saliva Human [1.28]
‐ Selenomonas Saliva Human [1.11]
‐ Selenomonas Supragingival plaque Human [1.13]
‐ Shuttleworthia satelles Supragingival plaque Human [1.12]
‐ Solobacterium Supragingival plaque Human [1.7]
‐ Staphylococcus warneri Supragingival plaque Human [1.12]
‐ Streptococcus mitis Biofilm sample Human [1.22]
‐ Streptococcus mutans Dental plaque Human [1.25]
‐ Streptococcus mutans Saliva Human [1.8]
‐ Streptococcus mutans Supragingival plaque Human [1.12]
‐ Streptococcus salivarius Saliva Human [1.29]
‐ Streptococcus sobrinus Saliva Human [1.30]
‐ Streptococcus vestibularis Saliva Human [1.29]
‐ Streptococcus Dental plaque Human [1.9]
‐ Streptococcus Plaque Human [1.16]
‐ Streptococcus Saliva Human [1.15]
‐ Streptococcus Subgingival plaque Human [1.31]
‐ Streptococcus Supragingival plaque Human [1.7]
‐ Treponema Supragingival plaque Human [1.13]
‐ Veillonella atypica Dental plaque Human [1.29]
‐ Veillonella atypica Saliva Human [1.29]
‐ Veillonella dispar Dental plaque Human [1.26]
‐ Veillonella dispar Saliva Human [1.29]
‐ Veillonella dispar Supragingival plaque Human [1.12]
‐ Veillonella parvula Dental plaque Human [1.26]
‐ Veillonella parvula Saliva Human [1.29]
‐ Veillonella sp. oral taxon 780 Saliva Human [1.8]
‐ Veillonellaceae Supragingival plaque Human [1.12]
‐ Veillonella Saliva Human [1.20]
‐ Veillonella Subgingival plaque Human [1.31]

↧ Microbiota

‐ Actinobacillus Saliva Human [1.20]
‐ Actinobaculum Saliva Human [1.30]
‐ Actinomyces naeslundii Dental plaque Human [1.26]
‐ Actinomyces naeslundii Plaque Human [1.10]
‐ Actinomyces Supragingival plaque Human [1.18]
‐ Aestuariimicrobium Dental plaque Human [1.9]
‐ Alloprevotella Saliva Human [1.15]
‐ Alternaria alternata Supragingival plaque Human [1.32]
‐ Aspergillus sydowii Supragingival plaque Human [1.17]
‐ Aureobasidium pullulans Supragingival plaque Human [1.17]
‐ Bacteroidetes Dental plaque Human [1.25]
‐ Bergeriella Supragingival plaque Human [1.13]
‐ Bergeyella Saliva Human [1.15]
‐ Burkholderia Plaque Human [1.33]
‐ Capnocytophaga ochracea Supragingival plaque Human [1.24]
‐ Capnocytophaga Plaque Human [1.33]
‐ Capnocytophaga Saliva Human [1.11]
‐ Capnocytophaga Subgingival plaque Human [1.31]
‐ Capnocytophaga Supragingival plaque Human [1.7]
‐ Cardiobacterium Plaque Human [1.10]
‐ Corynebacterium durum Dental plaque Human [1.26]
‐ Corynebacterium durum Supragingival plaque Human [1.18]
‐ Corynebacterium matruchotii Plaque Human [1.10]
‐ Corynebacterium matruchotii Supragingival plaque Human [1.24]
‐ Corynebacterium Saliva Human [1.20]
‐ Cystofilobasidium macerans Supragingival plaque Human [1.32]
‐ Debaryomyces Supragingival plaque Human [1.17]
‐ Delftia acidovorans Dental plaque Human [1.25]
‐ Eikenella Saliva Human [1.11]
‐ Filifactor Saliva Human [1.11]
‐ Filobasidium stepposum Supragingival plaque Human [1.32]
‐ Fretibacterium Saliva Human [1.11]
‐ Fusobacterium periodonticum Saliva Human [1.15]
‐ Fusobacterium Supragingival plaque Human [1.7]
‐ Haemophilus parainfluenzae Dental plaque Human [1.26]
‐ Haemophilus Saliva Human [1.11]
‐ Kingella Supragingival plaque Human [1.7]
‐ Lachnoanaerobaculum umeaense Saliva Human [1.15]
‐ Lachnospiraceae Dental plaque Human [1.25]
‐ Lautropia mirabilis Dental plaque Human [1.26]
‐ Lautropia mirabilis Supragingival plaque Human [1.18]
‐ Leptotrichia sp. oral clone FP036 Saliva Human [1.8]
‐ Leptotrichia Plaque Human [1.10]
‐ Leptotrichia Saliva Human [1.15]
‐ Leptotrichia Subgingival plaque Human [1.31]
‐ Leptotrichia Supragingival plaque Human [1.24]
‐ Malassezia globosa Supragingival plaque Human [1.19]
‐ Mitis group streptococci Plaque Human [1.33]
‐ Mucor racemosus Supragingival plaque Human [1.32]
‐ Mycoplasma Saliva Human [1.11]
‐ Mycosphaerella Supragingival plaque Human [1.17]
‐ Naganishia Supragingival plaque Human [1.17]
‐ Neisseria oralis Plaque Human [1.23]
‐ Neisseria Saliva Human [1.11]
‐ Neisseria Supragingival plaque Human [1.7]
‐ Ophiosphaerella Supragingival plaque Human [1.17]
‐ Papiliotrema flavescens Supragingival plaque Human [1.17]
‐ Penicillium expansum Supragingival plaque Human [1.32]
‐ Peptococcus Saliva Human [1.11]
‐ Porphyromonas pasteri Supragingival plaque Human [1.24]
‐ Porphyromonas Saliva Human [1.15]
‐ Porphyromonas Subgingival plaque Human [1.31]
‐ Prevotella intermedia Dental plaque Human [1.25]
‐ Prevotella nigrescens Saliva Human [1.30]
‐ Prevotella Plaque Human [1.33]
‐ Prevotella Supragingival plaque Human [1.24]
‐ Propionibacterium Saliva Human [1.11]
‐ Pseudomonas Saliva Human [1.20]
‐ Rhodotorula mucilaginosa Supragingival plaque Human [1.17]
‐ Rhynchogastrema tunnelae Supragingival plaque Human [1.17]
‐ Rothia aeria Dental plaque Human [1.26]
‐ Rothia aeria Plaque Human [1.10]
‐ Selenomonas noxia Supragingival plaque Human [1.24]
‐ Selenomonas Subgingival plaque Human [1.31]
‐ Selenomonas Supragingival plaque Human [1.21]
‐ Shigella Saliva Human [1.21]
‐ Sistotrema brinkmannii Supragingival plaque Human [1.17]
‐ Sistotremastrum suecicum Supragingival plaque Human [1.17]
‐ Staphylococcus epidermidis Saliva Human [1.14]
‐ Stomatobaculum Saliva Human [1.15]
‐ Streptococcus mitis Plaque Human [1.33]
‐ Streptococcus oralis Plaque Human [1.33]
‐ Streptococcus sanguinis Dental plaque Human [1.26]
‐ Streptococcus sanguinis Plaque Human [1.33]
‐ Streptococcus Saliva Human [1.11]
‐ Toxicocladosporium strelitziae Supragingival plaque Human [1.17]
‐ Weissella Saliva Human [1.21]

Impact by Microbiota

[ ]

↥ Metabolome

[ ]

↧ Metabolome

[ ]

Impact by Metabolome

‐ 3,3′-Diindolylmethane Protective ↥ Oronasal Human [1.3]

Related Factor

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Subclass

[ ]

References

[ ]

MetaBiom
Identifier: 40000204
URL: https://www.metabiom.org/disease/104/caries
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders [2023] [Review] [ACS Chemical Neuroscience] [Journal] [80003039]
[1.2] High-Throughput Sequencing of Oral Microbiota in Candida Carriage Sjögren’s Syndrome Patients: A Pilot Cross-Sectional Study [2023] [Study] [Journal of Clinical Medicine] [Journal] [80003046]
[1.3] 3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm [2023] [Antibiotics] [Journal] [80003444]
[1.4] Oral Microbiota: The Influences and Interactions of Saliva, IgA, and Dietary Factors in Health and Disease [2023] [Microorganisms] [Journal] [80003499]
[1.5] Fungal footprints in oral cancer: unveiling the oral mycobiome [2024] [Frontiers in Oral Health] [Journal] [80003705]
[1.6] The effects of nitrate on the oral microbiome: a systematic review investigating prebiotic potential [2024] [Journal of Oral Microbiology] [Journal] [80003838]
[1.7] Oral microbiome shifts from caries-free to caries-affected status in 3-year-old Chinese children: a longitudinal study [2018] [Frontiers in Microbiology] [Journal] [80000847]
[1.8] Salivary microbiome diversity in caries-free and caries-affected children [2016] [International journal of molecular sciences] [Journal] [80000542]
[1.9] Pyrosequencing analysis of oral microbiota in children with severe early childhood dental caries [2013] [Current Microbiology] [Journal] [80000436]
[1.10] Microbiome associated with severe caries in Canadian first nations children [2017] [Journal of Dental Research] [Journal] [80000802]
[1.11] Dynamic alterations in Salivary microbiota related to dental caries and age in preschool children with deciduous dentition: a 2-year follow-up study [2018] [Frontiers in Physiology] [Journal] [80000774]
[1.12] Amplicon-based microbiome study highlights the loss of diversity and the establishment of a set of species in patients with dentin caries [2019] [PLOS ONE] [Journal] [80001211]
[1.13] Taxonomic and functional analyses of the supragingival microbiome from caries-affected and caries-free hosts [2018] [Microbial Ecology] [Journal] [80000676]
[1.14] Profiling microorganisms in whole saliva of children with and without dental caries [2019] [Clinical and Experimental Dental Research] [Journal] [80001125]
[1.15] Salivary microbiota in individuals with different levels of caries experience [2017] [Journal of Oral Microbiology] [Journal] [80000452]
[1.16] Metagenomic investigation of bacteria associated with dental lesions: a cross-sectional study [2020] [Medicina Oral, Patologia Oral y Cirugia Oral] [Journal] [80001389]
[1.17] Site-specific profiling of the dental mycobiome reveals strong taxonomic shifts during progression of early-childhood caries [2020] [Applied and Environmental Microbiology] [Journal] [80001358]
[1.18] Sex-based diverse plaque microbiota in children with severe caries [2020] [Journal of Dental Research] [Journal] [80001351]
[1.19] Supragingival mycobiome and inter-kingdom interactions in dental caries [2020] [Journal of Oral Microbiology] [Journal] [80001411]
[1.20] Relationship of children’s salivary microbiota with their caries status: a pyrosequencing study. [2014] [Clinical oral investigations] [Journal] [80000348]
[1.21] The oral microbiome in the elderly with dental caries and health [2019] [Frontiers in Cellular and Infection Microbiology] [Journal] [80000970]
[1.22] The microbiome in populations with a low and high prevalence of caries [2016] [Journal of Dental Research] [Journal] [80000355]
[1.23] Oral microbiomes in children with asthma and dental caries [2019] [Oral Diseases] [Journal] [80001122]
[1.24] Bacterial biofilm composition in healthy subjects with and without caries experience [2019] [Journal of Oral Microbiology] [Journal] [80001244]
[1.25] Extensive description and comparison of human supra-gingival microbiome in root caries and health. [2015] [PLOS ONE] [Journal] [80000363]
[1.26] Microbiomes of site-specific dental plaques from children with different caries status [2017] [Infection and Immunity] [Journal] [80000599]
[1.27] Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries [2017] [npj Biofilms and Microbiomes] [Journal] [80000615]
[1.28] Comparison of the salivary and dentinal microbiome of children with severe-early childhood caries to the salivary microbiome of caries-free children [2019] [BMC Oral Health] [Journal] [80001257]
[1.29] Association between oral Candida and bacteriome in children with severe ECC [2018] [Journal of Dental Research] [Journal] [80000830]
[1.30] Temporal development of the oral microbiome and prediction of early childhood caries [2019] [Scientific Reports] [Journal] [80001267]
[1.31] Plaque bacterial microbiome diversity in children younger than 30 months with or without caries prior to eruption of second primary molars [2014] [PLOS ONE] [Journal] [80000314]
[1.32] Preliminary study of the oral mycobiome of children with and without dental caries [2018] [Journal of Oral Microbiology] [Journal] [80001240]
[1.33] Investigation of supragingival plaque microbiota in different caries status of Chinese preschool children by denaturing gradient gel electrophoresis [2011] [Microbial Ecology] [Journal] [80000323]

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Disease ⇒ Caries {40000204}

Record Keys

Details

Meta Information

Notes:

Shared Reference Notes

References Notes

Common References