Microbiome & Chronic Diseases

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Lactobacillus ⇒ Lactobacillus crispatus {10000211}

Record Keys

Lactobacillus crispatus


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Enzyme:[  ]
Function:[  ]


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Shared Reference Notes

  • [1.1
    - L. crispatus dominated microbiomes are generally associated with a high lactate content and acidic vaginal pH
  • [1.2] [#Bladder cancer
    - #Lactobacillus spp were significantly enriched in the #BCG responders. Co-culture with increasing concentrations of #Lactobacillus crispatus resulted in increased #BCG-GFP internalization in UCC when compared to controls
  • [1.3] [#Pregnancy] [#Lactobacillus gasseri
    - Tvaginal microbiota was mostly consistent with previously reported community sequence types. - Lactobacillus crispatus was the most abundant organism, followed by #Lactobacillus iners, #Gardnerella vaginalis, #Lactobacillus jensenii, and L. gasseri. - #Enterococcus faecalis was found in nearly 100% of samples, #Pseudomonas tolaasii in all samples, and #Escherichia coli in 83.75% of samples. #Streptococcus agalactiae was detected in 74% of samples and is an important pathogen in both mothers and #Infants.
  • [1.4] [#Lactobacillus jensenii] [#Vaginal Microbiome Transfer
    - After one VMT there was a complete shift in microbiome composition to 81.2% L. crispatus and 9% L. jensenii with a concurrent resolvement of vaginal symptoms. Single nucleotide polymorphism-analysis confirmed her microbiome to be of donor origin and it remain stable now 1.5 years after the VMT. - Five months after the VMT she became pregnant and has successfully delivered a healthy baby at term.
  • [1.5] [#Female infertility, #Normal Vaginal condition
    - Type 1 is the healthiest CST : Lactobacillus crispatus as the essential bacteria. - It prevents infections and health complications like infertility and #Preterm birth. - Type 1 has two subtypes, but both are highly protective.
  • [1.6] [#Normal Vaginal condition
    - L. crispatus PulA is active at the low pH values (~3.5–4) associated with vaginal health. This enzymatic activity may therefore enable L. crispatus to access #Glycogen under conditions where the human amylase is minimally active and the growth of competing bacteria is inhibited.

References Notes

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Common References