Disease ⇒ Cancer ⇒ Bladder cancer {40000147} Record Keys Type:Disease Parent:Cancer Definition:Bladder cancer Details Initialisation date:2020-09-06 Other Terms:[ ] LinksWickipediaMerck Manual Meta Information MedDra ID:10005003 MedDra Level:pt ICD:[ ] Category:Urology, Oncology Zone:[ ] Mechanism:[ ] Notes: - The most abundant phyla are Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, and Tenericutes. - The abundance of Proteobacteria was significantly higher among patients who had disease recurrence. - Firmicutes such as Lactobacillales were more abundant in patients who did not have disease recurrence. (1)Shared Reference Notes [1.1] - #Sulforaphane can normalize the intestinal flora imbalance of bladder cancer mice with a significant increase in #Bacteroides fragilis and #Clostridium cluster I [1.2] [#Lactobacillus crispatus] - #Lactobacillus spp were significantly enriched in the #BCG responders. Co-culture with increasing concentrations of #Lactobacillus crispatus resulted in increased #BCG-GFP internalization in UCC when compared to controls [1.3] - #Pelomonas > enriched in bladder cancer parenchyma, intestinal mucosa of #Crohn’s disease patients, and non-pregnant women’s endometrium. [1.4] - no differences between the urinary microbiome of healthy individuals and patients with bladder cancer, both in alpha and beta diversity - higher incidence of class #Alphaproteobacteria, order #Rhodospirillales, order #Flavobacteriales, and family #Flavobacteriaceae in female with bladder cancer. - the #Howardella genus and the #Streptococcus anginosus strain were more common in women. - no differences in the diversity of urine between sexes; however, in the urine of women, there was a higher abundance of the genera #Lactobacillus, Actinotignum, #Prevotella, #Veillonella, and #Campylobacter. - decreased abundance of #Clostridiales bacterium in the stools of bladder cancer patients, but increased #Streptococcus and #Escherichia. [#Clostridium group XI] - reduced abundance of #Clostridium cluster XI and #Prevotella in the gut microbiome of patients with bladder cancer. - #Lactobacillales were more abundant in the urine of patients undergoing #BCG therapy without recurrence, and the order #Enterobacterales was more abundant in the urine of patients with recurrence. - higher incidence of the genus #Klebsiella in the urine of female patients with bladder cancer.References Notes[ ]
