Microbiome & Chronic Diseases

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Disease ⇒ Systemic lupus erythematosus {40000134}

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Systemic lupus erythematosus
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Initialisation date:
Other Terms:
SLE , Lupus


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MedDra Level:
ICD:[  ]
Rheumatology, Immunology
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Mechanism:[  ]


- Mice with lupus had decreased amounts of Lactobacillus.
- The lupus mice had a "leaky gut" a condition that affects the intestinal lining.
- Addition of Lactobacillus to the diet only affected female mice and not males. (1)

- Women diagnosed with SLE had roughly five times more gut bacteria known as Ruminococcus gnavus.
- New treatments could also be used to promote growth of Bacteroides uniformis, bacteria thought to hinder growth of R. gnavus in the gut and whose numbers decreased by as much as fourfold in study participants with lupus when compared to those without the disease.
- Women diagnosed with SLE had roughly five times more gut bacteria known as Ruminococcus gnavus, than 17 women of similar ages and racial backgrounds who did not have the disease and were healthy.
- Disease "flares," which can range from instances of skin rash and joint pain to severe kidney dysfunction requiring dialysis, closely tracked major increases in R. gnavus bacterial growth in the gut, alongside the presence in blood samples of immune proteins called antibodies, specifically shaped to attach to the bacteria. Study participants with kidney flares had especially high levels of antibodies to R. gnavus.
- Strong immune antibody reactions to R. gnavus in the blood because the gut lining prevents the bacterium from escaping to other parts of the body. Researchers say this suggests that small pieces of the bacteria, known as antigens, must have "leaked" into the gut to trigger the immune reaction. (3)

References Notes

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Shared Reference Notes

  • [1.13
    - Vancomycin-treated mice showed an increase in Lactobacillus animalis in the gut, whereas there was a depletion in the total gut bacterial load. - Oral administration of L. animalis led to an exacerbation of lupus postpartum consisting of worsened splenomegaly and proteinuria while this did not affect the course of the disease in mice that were not pregnant or lactating. - L. animalis acted by inhibiting the serum enzyme indoleamine 2,3-dioxygenase alongside a differential production of immunosuppressive and pro-inflammatory mediators in the postpartum period. - The enriched L. animalis was involved in the vancomycin-driven effects on decreased T regulatory cells and increased pro-inflammatory cytokines. - Many Lupus patients have little or no detectable perturbations in representation of the Lachnospiraceae family or abundance of Ruminococcus gnavus species overtime.
  • [1.14
    - Anti-RG antibodies correlated directly with SLEDAI score and antinative DNA levels, but inversely with C3 and C4. - Intestinal expansions of Ruminococcus gnavus were directly proportional to overall disease activity and most pronounced in those with lupus nephritis. - Lupus faecal samples displayed increases in sIgA-coated Ruminococcus gnavus bacteria. - Patients with lupus nephritis displayed elevated serum IgG predominantly to Ruminococcus gnavus strain-restricted cell wall lipoglycan antigens.
  • [1.3
    - Bacilli and Lactobacillales were positively correlated with the risk of SLE. - Bacillales, Coprobacter and Lachnospira were negatively correlated with SLE risk. - Bacilli, Lactobacillales, and Eggerthella were risk factors for SLE. - Bacillales and Coprobacter served as protective factors for SLE. - Ruminiclostridium was negatively associated with SLE. - Actinobacteria might reduce the SLE risk.
  • [1.12
    - The SLE-enriched genera, including Bacteroides, were positively correlated with several SLE-enriched metabolites, including olopatadine. - The SLE-depleted genera, such as Pseudomonas, were negatively correlated to SLE-depleted cytokines, including interleukin-8. - Megamonas and Phocaeicola were negatively correlated with serum complement component 3, and Streptococcus was positively correlated with IgG.
  • - #Olopatadine, were more abundant in SLE patients. #Olopatadine appears to have significant anti-inflammatory activity, and inhibits histamine release from mast cells. Thus, the increase of #Olopatadine in urine might play a potential protective role for SLE patients.
  • [1.16
    - after #Staphylococcus aureus was epicutaneously applied on NfkbizΔK5 mice, NfkbizΔK5 mice developed SLE-associated autoantibodies, anti-dsDNA antibodies, anti-Sm antibodies, and glomerulonephritis with IgG deposition. - This staphylococcal skin colonization promoted caspase-mediated keratinocyte apoptosis and neutrophil activation, inducing the interleukin-23 (IL-23)/IL-17 immune response by activating dendritic cells and T cells. - the subcutaneous administration of anti–IL-23p19 and anti–IL-17A antibodies alleviated the systemic autoimmune response.

Common References