Antimicrobial peptides {90000176}
| Parent: | [ ] |
|---|---|
| Definition: | Antimicrobial peptides |
| Queue: | [ ] |
| Initialisation date: | [ ] |
|---|---|
| Specification: | |
cathelicidin, psoriasin, RNAse7 and dermcidin | |
| Source: | |
| [ ] | |
| Structural Type: | [ ] |
|---|---|
| Functional Type: | [ ] |
| Function: | [ ] |
Notes:
[ ]
Shared Reference Notes
- [1.1]
- Human hair follicle may manage its microbiome via the regulated production of antimicrobial peptides (such as cathelicidin, psoriasin, RNAse7 and dermcidin) by HF keratinocytes, - [1.2] [#Atopic Dermatitis]
- Atopic skin exhibits lower levels of certain HDPs such as #Dermcidin, human beta-defensin-2 (hBD-2), human beta-defensin-3 (hBD-3), and #Cathelicidin, as well as increased expression of #RNAse7 and S100A7 - [#Atopic Dermatitis] - Patients with AD exhibit decreased expression of antimicrobial peptides (AMPs) which is linked to increased colonization by #Staphylococcus aureus.
- [#Natural Skin Microbiome] [#Cathelicidin] - Host-derived AMPs, also known as host defence peptides (HDP)s are either constitutively produced by keratinocytes and immune cells or induced in response to stimuli such as pathogen-associated molecular patterns (PAMPs) or inflammatory cytokines. Some important classes of HDPs include RNases, defensins, cathelicidins, dermcidin, and S100 class peptides. - Some important classes of HDPs include RNases, defensins, cathelicidins, dermcidin, and S100 class peptides.
- - HDPs are well-known for their immunomodulatory and barrier-improving properties and play a critical role in the pathogenesis of diseases such as #Psoriasis and polymorphic light eruption underscoring the versatile role of HDPs in skin physiology
References Notes
[ ]