Disease ⇒ Colitis {40000146}
Type: | Disease |
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Definition: | Colitis |
Parent: | [ ] |
Initialisation date: | 2021-05-19 |
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Other Terms: | [ ] |
MedDra ID: | [ ] |
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MedDra Level: | [ ] |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.1]
-Colitis induction was dependent on the commensal microbiota such as B. ovatus and E. faecalis promoting the azo reduction of Red 40 and generation of a metabolite, 1-amino-2-naphthol-6-sulfonate sodium salt. - [1.2]
- triclosan (TCS), an antimicrobial agent found in thousands of consumer products > exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.
- intestinal commensal microbes > microbial β-glucuronidase (GUS) enzymes > mediate metabolic activation of triclosan in the colon > gut toxicology. - [1.3]
- C tropicalis > induces dysbiosis that involves changes in the presence of mucin-degrading bacteria Akkermansia muciniphila and Ruminococcus gnavus > leading to altered tight junction protein expression with increased intestinal permeability > followed by induction of robust Th1/Th17 responses > lead to an accelerated proinflammatory phenotype in experimental colitic mice. - [1.4]
- Brain’s insular cortex (InsCtx) stores immune-related information.
- Chemogenetic reactivation of these neuronal ensembles > broadly retrieve the inflammatory state under which these neurons were captured. - [1.6]
- Oral gavages of Klebsiella oxytoca, Escherichia coli, and Cronobacter sakazakii belonging to Enterobacteriaceae, singly or together, caused dose-dependently colitis and depression-like behaviors in germ-free and specific-pathogen-free mice. - [1.7]
- Salt consumption decreased Lactobacillus abundance, which was linked to increased T helper 17 cell numbers in murine small intestinal lamina propria lymphocytes and human peripheral blood lymphocytes, as well as higher blood pressure.
- a high-salt diet reduced Lactobacillus abundance, increased proinflammatory gene expression, and exacerbated colitis in two separate disease models - [1.8]
- S. epidermidis is predominantly a commensal skin microbe in humans but can also colonize the infant gut as a founding member in part through breastmilk seeding.
- S. epidermidis tends to disappear from the gut with age, its presence during early immune education may facilitate establishment of a largely tolerogenic intestinal memory CD4+ T cell pool.
- S. epidermidis can turn pathologic when it becomes bloodborne in an at-risk host. - [1.9]
- The protein expressed by the Bacteroides is almost identical to a protein expressed by insulin-producing cells in the pancreas.
- The CD8 lymphocytes can mistakenly attack the pancreatic cells and cause type 1 diabetes.