Microbiome & Chronic Diseases

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Disease ⇒ Colitis {40000146}

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Shared Reference Notes

  • [1.1] [#Food colorants
    -Colitis induction was dependent on the commensal microbiota such as B. ovatus and E. faecalis promoting the azo reduction of Red 40 and generation of a metabolite, 1-amino-2-naphthol-6-sulfonate sodium salt.
  • [1.2] [#Colorectal cancer, #Crohn’s disease, #Inflamatory bowel disease] [#Common consumer products
    - #Triclosan (TCS), an antimicrobial agent found in thousands of consumer products > exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models. - intestinal commensal microbes > microbial β-glucuronidase (GUS) enzymes > mediate metabolic activation of #Triclosan in the colon > gut toxicology.
  • [1.3] [#Crohn’s disease] [#Candida tropicalis
    - C tropicalis > induces dysbiosis that involves changes in the presence of mucin-degrading bacteria #Akkermansia muciniphila and #Ruminococcus gnavus > leading to altered tight junction protein expression with increased intestinal permeability > followed by induction of robust Th1/Th17 responses > lead to an accelerated proinflammatory phenotype in experimental colitic mice.
  • [1.4
    - Brain’s insular cortex (InsCtx) stores immune-related information. - Chemogenetic reactivation of these neuronal ensembles > broadly retrieve the inflammatory state under which these neurons were captured.
  • [1.6
    - Oral gavages of #Klebsiella oxytoca, #Escherichia coli, and #Cronobacter sakazakii belonging to Enterobacteriaceae, singly or together, caused dose-dependently colitis and #Depression-like behaviors in germ-free and specific-pathogen-free mice.
  • [1.7] [#Hypertension] [#High salt diet
    - Salt consumption decreased #Lactobacillus abundance, which was linked to increased T helper 17 cell numbers in murine small intestinal lamina propria lymphocytes and human peripheral blood lymphocytes, as well as higher blood pressure. - a high-salt diet reduced #Lactobacillus abundance, increased proinflammatory gene expression, and exacerbated colitis in two separate disease models
  • [1.8] [#Staphylococcus epidermidis] [#Breast feeding
    - S. epidermidis is predominantly a commensal skin microbe in humans but can also colonize the infant gut as a founding member in part through breastmilk seeding. - S. epidermidis tends to disappear from the gut with age, its presence during early immune education may facilitate establishment of a largely tolerogenic intestinal memory CD4+ T cell pool. - S. epidermidis can turn pathologic when it becomes bloodborne in an at-risk host.
  • [1.9] [#Diabetes Type 1
    - The protein expressed by the #Bacteroides is almost identical to a protein expressed by insulin-producing cells in the pancreas. - The CD8 lymphocytes can mistakenly attack the pancreatic cells and cause type 1 diabetes.