ZO-1 {90000589}

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ZO-1
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Shared Reference Notes

  • [1.1] 
    - sodium #Butyrate (NaB) inhibits NF-κB activation and restores the production of tight junction proteins ZO-1 and #Claudin-1 to block the vicious cycle of cytokine storms, improve intestinal barrier function, and increase the survival rate.
  • [1.2] [#Fiber-free diet, #Low fibre Diet] 
    - the lowest levels of tight junction proteins ZO-1 and #Occludin in TG mice challenged by fiber deprivation and #Curli.
  • [#Parkinson’s Disease] - In intestinal biopsies from patients with PD, especially #Occludin was found at lower levels, whereas ZO-1 was unchanged.
  • [1.3] [#Exercise training] 
    - Exercise increased the expression of #BDNF and decreased expression of Zo-1 and Claudin5 in the brain.
  • [1.4] 
    - reduction of membrane localization of tight junction protein (ZO-1, ZO-2, #Occludin, #Claudin-1, and -3) and increased permeability in colonocytes were induced by the #Ammonia treatment > mitochondrial dysfunction > increase of #Oxidative stress, > intestinal barrier dysfunction.
  • [1.5] [#Lactobacillus plantarum] 
    - treatment with #Lactobacillus plantarum L137 increased the abundance of #Lactobacillus species, improved intestinal barrier integrity via upregulation of ZO-1, as well as modulated cytokine levels. - In #Colitis mice, treatment with #Lactobacillus plantarum L137 ameliorated disease-associated changes and exhibited an anti-inflammatory effect.

References Notes

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