BDNF {60000085}

Shared Reference Notes

• [1.1] [#Anxiety] 
• [1.2] 
  - germ-free mice have reduced #Anxiety compared to specific pathogen free mice, which is correlated to reduced brain-derived neurotrophic factor (BDNF) expression in the amygdala.
• [#Condition of chronic stress] - in a model of chronic unpredictable mild stress, #Ferulic acid ameliorated depressive-like behaviors possibly through the upregulation of BDNF, postsynaptic protein PSD95 levels, and synapsin I in the prefrontal cortex and hippocampus
• [#Depression] [#Bifidobacterium animalis lactis, #Bifidobacterium bifidum, #Bifidobacterium longum, #Lactobacillus acidophilus] [#humanized Galactooligosaccharides] [#Combination of probiotics and polyphenol-rich prebiotics] - patients were administered a synbiotic containing L. acidophilus, B. bifidum, B. lactis, and B. longum with the prebiotics FOS, GOS and #Inulin. In a subset of patients with depressive symptoms, the synbiotic significantly reduced the depressive score compared to both the #Probiotic-alone and placebo groups, which correlated to an increase in BDNF serum levels.
• [1.3] [#Exercise training] 
  - Exercise increased the expression of Bdnf and decreased expression of #ZO-1 and Claudin5 in the brain.
• [1.4] [#Short Chain Fatty Acid] 
  - #Electro-acupuncture treatment effectively ameliorated both pain and #Depression-like behaviors. - Electro-acupunctureprofoundly reshaped the gut microbiota composition, notably increasing the abundance of SCFAs-producing bacteria, particularly #Akkermansia. - #Electro-acupuncture treatment > alterations of BDNF, HDAC2, and AcH3
• [1.5] [#Alzheimer’s disease] [#β-hydroxybutyrate] [#Keto diet] 
  - Alzheimer disease > KD’s ‘main actor’ is thought to be Beta-Hydroxy-butyrate (BHB) whose levels rose significantly in KD vs. CD mice, and BHB itself significantly rescued LTP in APP/PS1 hippocampi. - KD’s 6 most significant pathways induced in brains by RNAseq all related to Synaptic Plasticity. - KD induced significant increases in synaptic plasticity enzymes p-ERK and p-CREB in both sexes, and of brain-derived neurotrophic factor (BDNF) in APP/PS1 females.

References Notes