Palmitoleic acid {90000278} Record Keys Parent:[ ] Definition:Palmitoleic acid Queue:[ ] Details Initialisation date:2022-03-15 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory Notes: [ ]Shared Reference Notes [1.1] [#Akkermansia muciniphila, #Mycobacterium tuberculosis] [#Probiotic (A. muciniphila)] - Oral treatment of A. muciniphila or A. muciniphila-mediated palmitoleic acid strongly inhibits #Tuberculosis infection through epigenetic inhibition of tumour necrosis factor in mice infected with Mycobacterium #Tuberculosis. [#Akkermansia muciniphila] - single-nucleotide polymorphism #rs2257167 ‘G’ allele of type I interferon receptor 1 (encoded by IFNAR1 in humans) contributes to stronger type I interferon signalling, impaired colonization and abundance of A. muciniphila, reduced palmitoleic acid production, higher levels of tumour necrosis factor, and more severe #Tuberculosis disease in humans and transgenic mice [1.2] - POA significantly upregulated the transcriptional signatures of cell division and biosynthetic process of #Akkermansia muciniphila, selectively increased the growth and abundance of #Akkermansia muciniphila in gut microbiota. - co-administration of POA with #Akkermansia muciniphila showed significant synergistic protections against #Colitis in mice. [#Inflamatory bowel disease] [#Anti-TNF therapy] - Dietary palmitoleic acid (POA) repaired gut mucosal barriers, reduced inflammatory cell infiltrations and expressions of TNF-α and #IL-6, and improved efficacy of anti-TNF-α therapy in both acute and chronic IBD mouse models. [1.3] [#Cutibacterium acnes] - lipid extracted from neonatal human epidermal keratinocytes (NHEKs) after exposure to C. acnes CM or #Propionic acid has increased antimicrobial potency against C. acnes. - Many lipids potentially made by NHEK have antimicrobial activity including #Lauric acid, palmitoleic acid isomer (C16:1Δ6), sphingosine, and dihydrosphingosine [1.4] [#Autism] - omega-7 monounsaturated palmitoleic acid, (9Z)-hexadec-9-enoic acid (below the level of detection in 87.0% of future ASD but present in 43.5% of controls), and #Palmitic acid (elevated in future ASD). Palmitoleic acid has been associated with a decreased risk of islet and primary insulin autoimmunityReferences Notes[ ]
