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Microbiome & Chronic Diseases

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Disease ⇒ Systemic sclerosis {40000213}

Record Keys


Type:
Disease
Definition:
Systemic sclerosis
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:
SSc

Meta Information


MedDra ID:
10042953
MedDra Level:
llt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.3] [#Atherosclerosis
    - Trimethylamine (#TMA) is generated by the gut microbiome and in the host converted by flavin-containing monooxygenase (FMO3) into trimethylamine N-oxide (#TMAO), which has been implicated in chronic cardiovascular and metabolic diseases. - Using cell culture systems and patient biopsies > #TMAO reprograms skin fibroblasts, vascular endothelial cells, and adipocytic progenitor cells into myofibroblasts via the putative #TMAO receptor protein R-like endoplasmic reticulum kinase (PERK). - FMO3 was detected in skin fibroblasts and its expression stimulated by TGF-β1. - FMO3 was elevated in Systemic Sclerosis skin biopsies and in Systemic Sclerosis fibroblasts.