Retinoic acid {90000331} Record Keys Parent:[ ] Definition:Retinoic acid Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory, Anti-bacterial Notes: [ ]Shared Reference Notes [1.1] [#Short Chain Fatty Acid] - Injection of SCFAs has been shown to enhance retinoic acid (RA) in intentional epithelial cells. [1.2] [#Citrobacter rodentium] [#Vitamin A] - Commensal segmented filamentous bacteria protect against C. rodentium infection - Commensal bacteria express enzymes that generate retinoic acid in the intestine - Commensal bacterial-derived retinoic acid promotes epithelial defense in the host [1.3] [#Systemic lupus erythematosus] - in Mice > #Resistant Starch (RS), retinoic acid (RA) or all-trans retinoic acid (tRA), and acidic water (AW) had influenced the gut microbiome, leading to an improved lupus development. [1.4] - All-trans-retinoic acid treatment reversed pristane-induced leaky gut [1.5] [#Short Chain Fatty Acid] - SCFA administration stimulate retinoic acid (RA) production in the intestinal epithelium, a #vitamin #A derivate converted by #Aldehyde dehydrogenases, which is associated with signaling and expansion of peripheral Tregs (pTregs) in the context of a immunosuppressive response [1.6] - RA, have been suggested to exhibit beneficial effects in #Alzheimer’s disease by mechanisms that involve inhibiting the formation, elongation, and destabilizing effects of β-#Amyloid fibrils [#Colorectal cancer] - inflammation induced by gut #Bacteria impacts the metabolism of all-trans retinoic acid (AtRA), resulting in diminished levels of AtRA, this reduction in AtRA levels has been implicated in the advancement of #Ulcerative Colitis (UC) and its associated CRC References Notes[ ]
