Enterobacteriaceae ⇒ Salmonella {10000918}
Parent: | |
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Definition: | Salmonella |
Initialisation date: | [ ] |
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Rank: | Genus |
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Domain: | Bacteria |
Zone: | [ ] |
Enzyme: | [ ] |
Function: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- Salmonella spp. also induce #Cancer cells to produce the gap junction protein, connexin 43, which enhances the transfer and cross-presentation of processed tumor antigenic peptides between #Cancer cells and dendritic cells (DCs), and reduce the expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) - [1.2]
- #Indole has antipathogenic potential toward Salmonella by reducing the expression of virulence genes. - #Indole also exerts anti-inflammatory properties by counteracting the lipopolysaccharide (LPS)-induced inflammatory response and inhibiting pro-inflammatory activation of macrophages. - [1.3] [#Escherichia coli, #Helicobacter pylori, #Shigella flexneri]
- Notable genera in the #Proteobacteria are #Escherichia, Salmonella, #Shigella, #Desulfovibrio, and #Helicobacter. Included in the phyla is the #Enterobacteriaceae family, which contains several enteropathogenic bacteria, including #Shigella flexneri, Salmonella typhi, and #Escherichia coli. Other enteric pathogens in this phylum are #Vibrio cholerae and #Helicobacter pylori. - [1.4] [#Salmonella typhimurium]
- increased abundance of Salmonella in the gut microbiome of patients with #Gallbladder cancer (GBC) and culturable Salmonella Typhimurium from their GBC tissue. - Comparative genomics of S. Typhimurium isolated from GBC tissue showed a high invasive index. S. Typhimurium isolates harbored horizontally acquired potential virulence functions in their accessory genome. - Chronic S. Typhimurium infection displayed inflammation, pre-neoplastic changes and tumor promoting mechanisms in a mouse model with gallbladder stones, including activation of the epigenetic modulator Kdm6b. Inhibition of Kdm6B reduced tumor size in NOZ cells engrafted in SCID-mice. - [1.5] [#Short Chain Fatty Acid]
- An additional function of SCFAs is to lower the colonic luminal pH to inhibit growth of pathogens such as Salmonella and #Escherichia coli - [1.6]
- #Mannose can reduce colonization of pathogens by promoting #Mannose adhesion to Salmonella. #Mannose binds to Salmonella via type 1 fimbriae - [1.7]
- #Hydrogen sulfide may suppress the #Oxygen-dependent metabolism of some pathogens - #Taurinivorans muris has a protective role against #Klebsiella and Salmonella, two important gut pathogens.
References Notes
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