Enterobacteriaceae ⇒ Salmonella {10000918}

Shared Reference Notes

• [1.1] 
  - Salmonella spp. also induce #Cancer cells to produce the gap junction protein, connexin 43, which enhances the transfer and cross-presentation of processed tumor antigenic peptides between #Cancer cells and dendritic cells (DCs), and reduce the expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO)
• [1.2] 
  - #Indole has antipathogenic potential toward Salmonella by reducing the expression of virulence genes. - #Indole also exerts anti-inflammatory properties by counteracting the lipopolysaccharide (LPS)-induced inflammatory response and inhibiting pro-inflammatory activation of macrophages.
• [1.3] [#Escherichia coli, #Helicobacter pylori, #Shigella flexneri] 
  - Notable genera in the #Proteobacteria are #Escherichia, Salmonella, #Shigella, #Desulfovibrio, and #Helicobacter. Included in the phyla is the #Enterobacteriaceae family, which contains several enteropathogenic bacteria, including #Shigella flexneri, Salmonella typhi, and #Escherichia coli. Other enteric pathogens in this phylum are #Vibrio cholerae and #Helicobacter pylori.
• [1.4] [#Salmonella typhimurium] 
  - increased abundance of Salmonella in the gut microbiome of patients with #Gallbladder cancer (GBC) and culturable Salmonella Typhimurium from their GBC tissue. - Comparative genomics of S. Typhimurium isolated from GBC tissue showed a high invasive index. S. Typhimurium isolates harbored horizontally acquired potential virulence functions in their accessory genome. - Chronic S. Typhimurium infection displayed inflammation, pre-neoplastic changes and tumor promoting mechanisms in a mouse model with gallbladder stones, including activation of the epigenetic modulator Kdm6b. Inhibition of Kdm6B reduced tumor size in NOZ cells engrafted in SCID-mice.
• [1.5] [#Short Chain Fatty Acid] 
  - An additional function of SCFAs is to lower the colonic luminal pH to inhibit growth of pathogens such as Salmonella and #Escherichia coli
• [1.6] 
  - #Mannose can reduce colonization of pathogens by promoting #Mannose adhesion to Salmonella. #Mannose binds to Salmonella via type 1 fimbriae
• [1.7] 
  - #Hydrogen sulfide may suppress the #Oxygen-dependent metabolism of some pathogens - #Taurinivorans muris has a protective role against #Klebsiella and Salmonella, two important gut pathogens.

References Notes