Microbiome & Chronic Diseases

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Enterobacteriaceae ⇒ Salmonella {10000918}

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Shared Reference Notes

  • [1.1
    - Salmonella spp. also induce #Cancer cells to produce the gap junction protein, connexin 43, which enhances the transfer and cross-presentation of processed tumor antigenic peptides between #Cancer cells and dendritic cells (DCs), and reduce the expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO)
  • [1.2
    - #Indole has antipathogenic potential toward Salmonella by reducing the expression of virulence genes. - #Indole also exerts anti-inflammatory properties by counteracting the lipopolysaccharide (LPS)-induced inflammatory response and inhibiting pro-inflammatory activation of macrophages.
  • [1.3] [#Escherichia coli, #Helicobacter pylori, #Shigella flexneri
    - Notable genera in the #Proteobacteria are #Escherichia, Salmonella, #Shigella, #Desulfovibrio, and #Helicobacter. Included in the phyla is the #Enterobacteriaceae family, which contains several enteropathogenic bacteria, including #Shigella flexneri, Salmonella typhi, and #Escherichia coli. Other enteric pathogens in this phylum are #Vibrio cholerae and #Helicobacter pylori.
  • [1.4] [#Salmonella typhimurium
    - increased abundance of Salmonella in the gut microbiome of patients with #Gallbladder cancer (GBC) and culturable Salmonella Typhimurium from their GBC tissue. - Comparative genomics of S. Typhimurium isolated from GBC tissue showed a high invasive index. S. Typhimurium isolates harbored horizontally acquired potential virulence functions in their accessory genome. - Chronic S. Typhimurium infection displayed inflammation, pre-neoplastic changes and tumor promoting mechanisms in a mouse model with gallbladder stones, including activation of the epigenetic modulator Kdm6b. Inhibition of Kdm6B reduced tumor size in NOZ cells engrafted in SCID-mice.
  • [1.5] [#Short Chain Fatty Acid
    - An additional function of SCFAs is to lower the colonic luminal pH to inhibit growth of pathogens such as Salmonella and #Escherichia coli
  • [1.6
    - #Mannose can reduce colonization of pathogens by promoting #Mannose adhesion to Salmonella. #Mannose binds to Salmonella via type 1 fimbriae
  • [1.7
    - #Hydrogen sulfide may suppress the #Oxygen-dependent metabolism of some pathogens - #Taurinivorans muris has a protective role against #Klebsiella and Salmonella, two important gut pathogens.

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