Disease ⇒ Cancer ⇒ Esophageal cancer {40000175}
| Type: | Disease |
|---|---|
| Parent: | |
| Definition: | Esophageal cancer |
| Initialisation date: | 2020-09-01 |
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| Other Terms: | [ ] |
| MedDra ID: | 10030155 |
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| MedDra Level: | pt |
| ICD: | [ ] |
| Category: | Gastroenterology, Oncology |
| Zone: | [ ] |
| Mechanism: | [ ] |
Notes:
- P. gingivalis was detected immunohistochemically in 61 % of cancerous tissues, 12 % of adjacent tissues and was undetected in normal esophageal mucosa. A similar distribution of lysine-specific gingipain, a catalytic endoprotease uniquely secreted by P. gingivalis, and P. gingivalis 16S rDNA was also observed.
- P. gingivalis infection positively associated with multiple clinicopathologic characteristics, including differentiation status, metastasis, and overall survival rate. (1)
Shared Reference Notes
- [1.1]
- The presence of oral P. gingivalis and T. forsythia associate with an increased risk of esophageal cancer. - P. gingivalis and T. forsythia are included in signaling pathways responsible for cancer development. - T. forsythia may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α. - gingipain K produced by P. gingivalis, affects hosts immune system by degradation of immunoglobulins and complement system. - [1.2] [#Cladosporium cladosporiode]
- In a mouse model of esophageal cancer, oral fungi Cladosporium cladosporiodes reportedly increased the severity of ESCC, which was, interestingly reversed by antifungal treatment. - - infections #HPV and #EBV reportedly increased risk of esophageal squamous cell carcinoma
- [1.3] [#Head & Neck cancer, #Oral cancer]
- Among streptococci, #Streptococcus anginosus seems to be an especially relevant marker of head, neck, and esophageal cancers - [1.4] [#Biliary tract cancer, #Colorectal cancer, #Gallbladder cancer, #Pancreatic Cancer]
References Notes
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