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Disease ⇒ Esophageal cancer ⇒ Cancer {40000175}

Record Keys


Type:
Disease
Definition:
Esophageal cancer
Parent:

Details


Initialisation date:
2020-09-01
Other Terms:[  ]

Links


Meta Information


MedDra ID:
10030155
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology, Oncology
Zone:[  ]
Mechanism:[  ]

Notes:


- P. gingivalis was detected immunohistochemically in 61 % of cancerous tissues, 12 % of adjacent tissues and was undetected in normal esophageal mucosa. A similar distribution of lysine-specific gingipain, a catalytic endoprotease uniquely secreted by P. gingivalis, and P. gingivalis 16S rDNA was also observed.
- P. gingivalis infection positively associated with multiple clinicopathologic characteristics, including differentiation status, metastasis, and overall survival rate. (1)

References Notes


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Shared Reference Notes


  • [1.4
    - The presence of oral P. gingivalis and T. forsythia associate with an increased risk of esophageal cancer. - P. gingivalis and T. forsythia are included in signaling pathways responsible for cancer development. - T. forsythia may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α. - gingipain K produced by P. gingivalis, affects hosts immune system by degradation of immunoglobulins and complement system.
  • [1.2
    - In a mouse model of esophageal cancer, oral fungi #Cladosporium cladosporiodes reportedly increased the severity of ESCC, which was, interestingly reversed by antifungal treatment.
  • - infections #HPV and #EBV reportedly increased risk of esophageal squamous cell carcinoma

Common References