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Disease ⇒ Chronic Obstructive Pulmonary Disease {40000195}

Record Keys


Type:
Disease
Parent:[  ]
Definition:
Chronic Obstructive Pulmonary Disease

Details


Initialisation date:
2021-02-09
Other Terms:
COPD

Meta Information


MedDra ID:
10009033
MedDra Level:
pt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.16
    - Lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD particularly by the dysbiosis of the members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera.
  • [1.17
    - The oral and pulmonary mycobiomes from controls and participants with COPD were dominated by #Candida - Malassezia and Sarocladium were also frequently found in pulmonary samples.
  • [1.19] [#Smoking
  • [1.20] [#Bufei Jianpi formula
    - BJF administration > increased the abundance of Firmicutes and the ratio of Firmicutes to Bacteroides, raising SCFA levels, including acetate, butyrate, and propionate levels. - However, the abundance of Bacteroidetes, Proteobacteria, Spirochaetes, Clostridiaceae, and Treponema decreased. - BJF decreased the gene and protein expression of NLRP3, Caspase-1, IL-8, and IL-1β, and increased GPR43 expression.
  • [1.21] [#Cystic fibrosis exacerbation, #non-cystic fibrosis bronchiectasis
  • [1.15] [#Indole-3-acetic acid (IAA)
    - In Neutrophil-predominant COPD altered #Tryptophan metabolism in airway #Lactobacilli is associated with reduced indole-3-acetic acid (IAA), which was in turn linked to perturbed host interleukin-22 signalling and epithelial cell apoptosis pathways. - airway microbiome-derived IAA mitigates neutrophilic inflammation, apoptosis, emphysema and lung function decline, via macrophage–epithelial cell cross-talk mediated by interleukin-22. - Intranasal inoculation of two airway #Lactobacilli restored IAA and recapitulated its protective effects in mice.

Common References