Disease ⇒ Intermittent Hypoxia {40000653}

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Intermittent Hypoxia


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Shared Reference Notes

  • [1.1] [#Obstructive sleep apnea-hypopnea syndrome
    - gut microbiome changes associated with IH can independently cause #Sleep disturbances in mice. - The #Sleep disorders observed in mice resemble the excessive daytime sleepiness commonly found in individuals with OSA.
  • - In chronic intermittent hypoxia (CIH) mice, beneficial genera like #Clostridium, #Akkermansia, and #Bacteroides reduced in presence while pathogenic genera like #Desulfovibrio increased.
  • - IH mice exhibited increased levels of #Desulfovibrio, a bacterium that adversely impacts the intestinal barrier, contributing to the disruption of the intestinal barrier.
  • [#Lipopolysaccharide] - plasma concentrations of LPS in mice exposed to IH remained significantly increased even after 6 weeks of normoxic recovery. - gut dysbiosis still persisted after exposure to normoxia.
  • - IH affects the arterial partial pressure of #Oxygen, which could result in a hypoxia/reoxygenation pattern within the gut
  • [1.2] [#Deoxycholic acid, #Lithocholic acid
    - #Ruminococcaceae families perform the subsequent 7α-dehydroxylation of CA and CDCA to respectively generate DCA and LCA, has been associated with intermittent hypoxia and hypercapnia conditions

References Notes

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