Sleep Deprivation {51111282}

Shared Reference Notes

• [1.1] 
  - fecal #Butyrate concentrations positively correlated with the relative abundance of #Butyricimonas. - the abundance of SCFAs-producing microbes, such as #Butyricicoccus, #Butyricimonas, and #Alistipes markedly decreased after SD. - #Butyrate > significantly reduced after 48 h of SD > After 1 week of sleep recovery, #Butyrate concentrations returned.
• - gut microbial composition and metabolites did not change in the rats after 24 h of SD but were significantly altered after 48 h of Sleep Deprivation > reversible after 1 week of sleep recovery. - After 48 h of SD, the relative abundance of Butyricicoccus, Butyricimonas, Alistipes, Intestinimonas, and Lactobacillus decreased, whereas the relative abundance of Streptococcus increased.
• - #Streptococcus was negatively correlated with the concentration of fecal #Butyrate and positively correlated with the KEGG pathway of #Lipopolysaccharide biosynthesis.
• [1.2] 
  - Decreases in SCFA-producing bacteria, specifically belonging to #Akkermansia and #Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical sleep deprivation and 3-day continuous sleep deprivation. - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption. - sleep deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of #Lactobacillus plantarum.
• [1.3] [#Alzheimer’s disease] 
  - #Sleep deprivation exacerbates AD pathology, which clearly connects poor #Sleep quality with progression of AD.
• [1.4] [#Polyphenols] 
  - Dietary Polyphenol Preparation (BDPP) containing GSPE, concord #Grape juice and #Resveratrol was shown to attenuate sleep deprivation-induced contextual memory deficits.
• [1.5] [#Social jetlag] 
• [1.6] [#Lipopolysaccharide] 
  - SF (Sleep Frgamentation) modifies the gut microbiome, leading to an elevation in the #Lachnospiraceae family and a decline in the #Lactobacillaceae family. - The former is associated with intestinal inflammation, whereas the latter acts as a protective barrier. - SF lowers antioxidant capacity and depletes the number of goblet cells and colonocyte proliferation.36 It also intensifies LPS-binding protein circulation levels and stimulates an enhanced inflammatory response.
• [1.7] 
  - in Sleep deprivation C57BL/6 J mice, the abundance of #Tannerellaceae in the gut showed a positive correlation with the levels of pro-inflammatory cytokines

References Notes