Disease ⇒ Fatigue {40000509} Record Keys Type:Disease Parent:[ ] Definition:Fatigue Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10016256 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Vitamin B12] - The neurologic complications of B12 deficiency occur at a later stage of depletion and was associated with severe symptoms of #Depression, suicidal behaviors, reduced cognition, mental fatigue, bad or depressed moods, mania, psychosis, and intense agitation [1.2] [#Inflamatory bowel disease] - IBD Patient > Leukemia inhibitory factor receptor (LIF-R) concentrations were inversely associated with severe fatigue [1.3] [#Chronic fatigue syndrome] [#IL-17A] - Fluctuations in IL-17 have been associated with fatigue and fatigue severity in ME/CFS patients [#Chronic fatigue syndrome] - Increased levels of #Leptin have been associated with higher fatigue scores in people with CFS. [#Chronic fatigue syndrome] - daily fatigue severity was significantly correlated with daily serum #Leptin levels in women with CFS [1.4] - Dietary #Trigonelline supplementation in male mice enhances #Muscle strength and prevents fatigue during ageing. [#Sarcopenia] - #Trigonelline improved grip strength and fatigue independently of changes in muscle mass and maximal tetanic strength. - benefits of #Trigonelline on muscle performance did not arise from structural adaptations in the skeletal muscle architecture, such as myofibre cross-sectional area, vascularization and fibrosis, but were linked to functional improvements of the mitochondrial respiratory activity of complexes I and II.References Notes[ ]
