IL-17A {60000086} Record Keys Parent:[ ] Definition:IL-17A Queue:[ ] Details Initialisation date:2020-10-04 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Pro-inflammatory Notes: [ ]Shared Reference Notes [1.1] - IL-17A is expressed in mucosal cells and contributes to intestinal homeostasis but might promote inflammation in excess. - IL-17A is mainly produced by Th17 cells. It can also be produced by γδ T cells, natural killer (NK) T cells, macrophages, neutrophils, and eosinophils, but their regulation of IL-17A expression is different. - IL-17 molecules from the gut can influence autoimmune diseases in the central nervous system by regulating the gut microbiota rather than directly triggering brain inflammation [1.2] [#Parkinson’s Disease] - #Collinsella was associated with a higher level of pro-inflammatory IL-17A, > exacerbate neuroinflammation especially microglial activation in PD rodent model [1.3] - The peptide “YLYDGRIFI” similar to human Sm antigen epitope from #Odoribacter splanchnicus increased secretion of IFN-γ and IL-17A. [1.4] [#Chronic fatigue syndrome] - Fluctuations in IL-17 have been associated with #Fatigue and #Fatigue severity in ME/CFS patients - IL-17A has been found to be associated with neurological sequelae and pulmonary #Fibrosis in post-#Covid-19 patients [1.5] [#Multiple Sclerosis] - MS > bacterial species more abundant in clinically active treatment-naïve cases were positively associated with circulating levels of pro-inflammatory cytokines #IL-22, IL-17A, IFN-β, IL-33, and TNF-α. [1.6] [#Staphylococcus epidermidis] - The eyes with Fungal #Keratitis in the study showed a lower abundance of #Staphylococcus. - #Staphylococcus epidermidis was reported to be skin commensal and could offer heterologous protection against pathogenic fungal infections through induction of IL-17A + CD8 + T cells.References Notes[ ]
