Disease ⇒ Gout {40000127}
Type: | Disease |
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Parent: | [ ] |
Definition: | Gout |
Initialisation date: | 2020-09-06 |
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Other Terms: | Podagra arthritis uric acid Hyperuricemia |
MedDra ID: | [ ] |
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MedDra Level: | [ ] |
ICD: | [ ] |
Category: | Rheumatology |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- [1.2] [#Butyrate]
- [1.3] [#Uric acid] [#Antibiotic Therapy]
- Ablation of the microbiota in uricase-deficient mice causes severe #Hyperuricemia - anaerobe-targeted antibiotics increase the risk of gout in humans. - [#Xanthine] - #Uric acid elimination is facilitated by the enzyme uricase. - Human uricase is a pseudogene, having been inactivated early in hominid evolution. - anaerobic #Uric acid metabolism is widespread among members of the human gut.
- [1.4]
- In gout, #Bacteroides caccae and #Bacteroides xylanisolvens are enriched. - #Faecalibacterium prausnitzii and #Bifidobacterium pseudocatenulatum depleted. - The established reference microbial gene catalogue for gout revealed disorder in purine degradation and #Butyric acid biosynthesis in gout patients. - Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of #Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes. - #Bacteroides caccae is one biomarker of IBD. OmpW protein produced by B. caccae is a target of the IBD-associated immune response, thus the enriched intestinal B. caccae in gout patients could potentially induce serious inflammatory response. - #Faecalibacterium prausnitzii has anti-inflammatory properties and contribute to gut health through butyrate production. for gout patients, potentially explaining the decline in #Butyric acid biosynthesis in gout patients.
References Notes
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