Disease ⇒ Gout {40000127}

References Notes

Shared Reference Notes

• [1.3] 
  - In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched.
  - Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted.
  - The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients.
  - Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes.
  - Bacteroides caccae is one biomarker of IBD. OmpW protein produced by B. caccae is a target of the IBD-associated immune response, thus the enriched intestinal B. caccae in gout patients could potentially induce serious inflammatory response.
  - Faecalibacterium prausnitzii has anti-inflammatory properties and contribute to gut health through butyrate production. for gout patients, potentially explaining the decline in butyric acid biosynthesis in gout patients.