Disease ⇒ Gout {40000127}
Type: | Disease |
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Definition: | Gout |
Parent: | [ ] |
Initialisation date: | 2020-09-06 |
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Other Terms: | Podagra arthritis uric acid Hyperuricemia |
MedDra ID: | [ ] |
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MedDra Level: | [ ] |
ICD: | [ ] |
Category: | Rheumatology |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.3]
- In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched.
- Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted.
- The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients.
- Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes.
- Bacteroides caccae is one biomarker of IBD. OmpW protein produced by B. caccae is a target of the IBD-associated immune response, thus the enriched intestinal B. caccae in gout patients could potentially induce serious inflammatory response.
- Faecalibacterium prausnitzii has anti-inflammatory properties and contribute to gut health through butyrate production. for gout patients, potentially explaining the decline in butyric acid biosynthesis in gout patients.