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Disease ⇒ Gout {40000127}

Record Keys


Type:
Disease
Definition:
Gout
Parent:[  ]

Details


Initialisation date:
2020-09-06
Other Terms:
Podagra arthritis uric acid Hyperuricemia

Links


Meta Information


MedDra ID:[  ]
MedDra Level:[  ]
ICD:[  ]
Category:
Rheumatology
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.1] [#Butyrate
  • [1.3
    - In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched. - Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted. - The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients. - Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes. - Bacteroides caccae is one biomarker of IBD. OmpW protein produced by B. caccae is a target of the IBD-associated immune response, thus the enriched intestinal B. caccae in gout patients could potentially induce serious inflammatory response. - Faecalibacterium prausnitzii has anti-inflammatory properties and contribute to gut health through butyrate production. for gout patients, potentially explaining the decline in butyric acid biosynthesis in gout patients.

Common References