Disease ⇒ Gout {40000127}
| Type: | Disease |
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| Definition: | Gout |
| Parent: | [ ] |
| Initialisation date: | 2020-09-06 |
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| Other Terms: | Podagra arthritis uric acid Hyperuricemia |
| MedDra ID: | [ ] |
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| MedDra Level: | [ ] |
| ICD: | [ ] |
| Category: | Rheumatology |
| Zone: | [ ] |
| Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.1] [#Butyrate]
- [1.3]
- In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched. - Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted. - The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients. - Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes. - Bacteroides caccae is one biomarker of IBD. OmpW protein produced by B. caccae is a target of the IBD-associated immune response, thus the enriched intestinal B. caccae in gout patients could potentially induce serious inflammatory response. - Faecalibacterium prausnitzii has anti-inflammatory properties and contribute to gut health through butyrate production. for gout patients, potentially explaining the decline in butyric acid biosynthesis in gout patients.