Polyphenols ⇒ Fisetin {90000507} Record Keys Parent:Polyphenols Definition:Fisetin Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Anti-inflammatory Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] [#Escherichia] - The Fisetin group gut microbiota exhibited a significantly higher abundance of #Lachnospiraceae and a significantly lower abundance of uncultured_bacterium_g_Bacillus and uncultured_bacterium_g_Escherichia-Shigella. - patients with PD exhibited a lower abundance of #Lachnospiraceae than healthy control. - the abundance of #Lachnospiraceae was reduced by 42.9%, while that of #Bifidobacteriaceae was enriched in patients with PD. - fisetin may exert its neuroprotective effect by increasing the abundance of #Lachnospiraceae, which alleviates gut inflammation and reduces the production of toxic substances. - intestinal #Lachnospiraceae in patients with PD decreased with a concomitant decrease in the SCFA levels. - #Lachnospiraceae can promote the aggregation of regulatory T cells in the colon and reduce the immunoglobulin E level, while regulatory T cells can delay the dopaminergic neurodegeneration in PD [#Parkinson’s Disease] - Fisetin, a flavanol from fruits and vegetables, exerts anti-oxidant, anti-inflammatory, and anti-#Aging effects in MPTP induced mice model of PD - the neuroprotective effect of fisetin in the MPTP (1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine) mouse model of PD, which may be closely related to attenuation of α-synuclein expression. [1.2] - fisetin shown to suppress TNF-α production by macrophages and microglia cells in vitro - fisetin effects in a mouse model of ischemic #Stroke highlighted the flavanol’s ability to inhibit post-ischemic infiltration of macrophages and DCs as well as repress the intracerebral activation of immune cells References Notes[ ]
