Clostridium ⇒ Clostridium perfringens {10000711} Record Keys Parent:Clostridium Definition:Clostridium perfringens Details Initialisation date:[ ] Meta Information Rank: Species Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Clostridium perfringens also metabolizes tryptophan to #Tryptamine, a metabolite that decreases macrophage inflammatory indicators and reduces pro-inflammatory cytokines stimulated by fatty acids and LPS. [1.2] [#Neuromyelitis optica] - Neuromylitis optica Patients with anti-AQP4 antibodies have been shown to develop cross-reactivity to a homologous peptide sequence within a protein of Clostridium perfringens, a bacterium found to be more abundant in patients with NMO and able to generate a Th17 response, which is involved in autoimmune diseases [1.3] - small-molecule metabolites from gram-positive bacteria (including Clostridium perfringens and #Clostridium ramosum strains) and gram-negative bacteria (including multiple #Morganella morganii strains) directly damaged DNA in cell-free assays and induced the expression of the DSB marker γ-H2AX and cell-cycle arrest in epithelial cells. [1.4] - MS were more likely to harbor and show a greater abundance of #Epsilon toxin (ETX)-producing strains of C. perfringens within their gut microbiomes compared to healthy controls (HC). - ETX-induced EAE caused demyelination in the corpus callosum, thalamus, cerebellum, brainstem, and spinal cord, more akin to the neuroanatomical lesion distribution in MS. [1.5] - C. perfringens > production of exotoxin, #pfoA, has been shown to be regulated by short-chain fatty acids such as #Acetate and #Butyrate > inhibit #pfoA exotoxin. [1.6] - #Firmicutes, such as #Clostridium botulinum, Clostridium tetani, Clostridium perfringens, and #Staphylococcus aureus, can produce proteinaceous toxins. [1.7] - wheat fiber, may have therapeutic effects on patients with #Autism by decreasing the population of Clostridium perfringens and increasing the rate of #BifidobacteriaReferences Notes[ ]
