Clostridium ⇒ Clostridium perfringens {10000711}
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| Definition: | Clostridium perfringens |
| Initialisation date: | [ ] |
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| Rank: | Species |
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| Domain: | Bacteria |
| Zone: | [ ] |
| Enzyme: | [ ] |
| Function: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- Clostridium perfringens also metabolizes tryptophan to #Tryptamine, a metabolite that decreases macrophage inflammatory indicators and reduces pro-inflammatory cytokines stimulated by fatty acids and LPS. - [1.2] [#Neuromyelitis optica]
- Neuromylitis optica Patients with anti-AQP4 antibodies have been shown to develop cross-reactivity to a homologous peptide sequence within a protein of Clostridium perfringens, a bacterium found to be more abundant in patients with NMO and able to generate a Th17 response, which is involved in autoimmune diseases - [1.3]
- small-molecule metabolites from gram-positive bacteria (including Clostridium perfringens and #Clostridium ramosum strains) and gram-negative bacteria (including multiple #Morganella morganii strains) directly damaged DNA in cell-free assays and induced the expression of the DSB marker γ-H2AX and cell-cycle arrest in epithelial cells. - [1.4]
- MS were more likely to harbor and show a greater abundance of #Epsilon toxin (ETX)-producing strains of C. perfringens within their gut microbiomes compared to healthy controls (HC). - ETX-induced EAE caused demyelination in the corpus callosum, thalamus, cerebellum, brainstem, and spinal cord, more akin to the neuroanatomical lesion distribution in MS. - [1.5]
- C. perfringens > production of exotoxin, #pfoA, has been shown to be regulated by short-chain fatty acids such as #Acetate and #Butyrate > inhibit #pfoA exotoxin.
References Notes
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