Fungi {50002476} Record Keys Parent:[ ] Definition:Fungi Details Initialisation date:[ ] Meta Information Rank:Kingdom Domain:Fungi Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Pancreatic Cancer] -pancreatic ductal adenocarcinoma (PDA) tumours in humans and mouse models of this #Cancer displayed an increase in fungi of about 3,000-fold compared to normal pancreatic tissue. - the fungal community that infiltrated PDA tumours was markedly enriched for #Malassezia spp. in both mice and humans. - Ablation of the mycobiome was protective against tumour growth in slowly progressive and invasive models of PDA, - repopulation with a #Malassezia species—but not species in the genera Candida, Saccharomyces or Aspergillus—accelerated oncogenesis. - ligation of mannose-binding lectin (MBL), which binds to glycans of the fungal wall to activate the complement cascade, was required for oncogenic progression, - Deletion of MBL or C3 in the extratumoral compartment—or knockdown of C3aR in tumour cells—were both protective against tumour growth. [1.2] - in the gut, dead fungi are nutrients for bacterial fermentation. [1.3] [#Postmenopausal osteoporosis] - In PMO. Considering the positive association between #Devriesia and Bone Material Density, and the negative association between #Montagnulaceae and BMD, the two fungi species may play the beneficial and harmful roles during #Osteoporosis, respectively. [1.4] [#Eucalyptus oil] - 1,8-#Cineole, the major component of EC, is the potent antimicrobial ingredient, as it has been found effective against many #Bacteria, fungi, and viruses. - the higher the 1,8-#Cineole concentration, the greater the antimicrobial action. - 1,8-#Cineole can induce oxidative stress, causing bacterial membrane damage and leakage of the intercellular components. - EO can allow better membrane permeability for the conjugated antimicrobial agents, which can facilitate targeting intracellular components of such microorganisms [1.5] [#Multiple Sclerosis] - gut resident fungi (mycobiome) are also modulated in MS characterized by a reduced abundance of #Saccharomyces [1.6] - #Chitin (β-1,4-poly-N-acetylglucosamine) is a highly abundant natural #Polysaccharide found in arthropods and fungi that can initiate type 2 (allergic) immune responses. [1.7] [#Gastric carcinoma] - The abundance of fungi in the saliva and tongue coating of GC patients is lower than that of healthy controls within a single sample (alpha diversity).References Notes[ ]
