Disease ⇒ Osteoporosis ⇒ Postmenopausal osteoporosis {40000566} Record Keys Type:Disease Parent:Osteoporosis Definition:Postmenopausal osteoporosis Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Romboutsia, unclassified_Mollicutes, and Weissella spp. were enriched in the control group, whereas the abundances of Fusicatenibacter, Lachnoclostridium, and Megamonas spp. were higher in the osteoporosis group than in the other groups. Additionally, for VM, Lactobacillus was enriched in the control group, whereas the abundances of Peptoniphilus, Propionimicrobium, and Gallicola spp. were higher in the osteoporosis group than in the other groups. [1.2] - In PMO. Considering the positive association between #Devriesia and Bone Material Density, and the negative association between #Montagnulaceae and BMD, the two #Fungi species may play the beneficial and harmful roles during #Osteoporosis, respectively. - Lower gut microbiome diversity and a shift toward greater similarity to the male gut microbiome were confirmed in PMO patients - the enrichment #Lactobacillus sp. in non-PMO and the increased abundances of #Peptoniphilus sp., #Propionic acid bacteria, and members of the #Galicola genus in PMO - some novel metabolites, such as #Levulinic acid and #Pimelic acid, were significantly up-regulated in PMO population compared to non-PMO patients. [1.3] [#Lipopolysaccharide] - #Estrogen deficiency, the permeability of the gut increases leading to the translocation of harmful pathogens and the production of antigens (LPS) in the systemic circulation. [1.4] [#Osteoporosis] References Notes[ ]
