5-hydroxytryptamine {90000350} Record Keys Parent:[ ] Definition:5-hydroxytryptamine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Diabetes Type 2] [#Tryptophan] - 5-hydroxytryptamine (5-HT) is a Trp-catabolite formed by Trp hydroxylase 1 enzyme. - It promotes insulin secretion from pancreatic β-cells and inhibits hyperglycaemia and #Obesity. [1.2] [#Ruminococcus gnavus] - R. gnavus is capable of producing #Tryptamine, which can affect gut motility through several mechanisms. - First, #Tryptamine activates the #Serotonin receptor 4 (SR4) or 5-hydroxytryptamine receptor 4 (5-HT4R), leading to an increase in intracellular cyclic #Adenosine monophosphate (cAMP) concentration > This elevation in cAMP levels can enhance gut motility. - Second, #Tryptamine can also increase fluid secretion by acting on the cystic fibrosis transmembrane regulator (CFTR) > promotes the secretion of fluids into the gut, affecting gut motility.References Notes[ ]
