Genome {51111192} Record Keys Definition:Genome Queue:[ ] Details Initialisation date:2021-05-01 Specification: [ ] Meta Information Type:Genetic Host: Human, Mouse Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] - The microbial genomes within each of our microbiomes contain an estimated 100 times the gene content as our own genome . This genetic material is sometimes referred to as our ‘second genome’, as the coding potential of the microbiome greatly expands upon the coding potential our own genome. [1.2] - 16S rRNA transcript-based heritability estimates are positively correlated with cospeciation rate estimates. Genome-wide association mapping identifies 428 loci influencing 120 taxa, with narrow genomic intervals pinpointing promising candidate genes and pathways. [1.3] - In neurodegenerative diseases > #Histamine and other important #Neurotransmitters were synthesized in reduced amounts by the microbes with an elevated population in the diseased state. - Most of the microbes, except #Desulfovibrio, #Lactobacillus, and #Streptococcus, showed no annotation in their genome to synthesize #Histamine. [1.4] - In addition to #Bifidobacterium and #Lactobacillus, our study found a significant enrichment of #Streptococcus, a #Lactic acid-producing bacteria, in patients with #Ulcerative Colitis (UC). - This is in contrast to the majority of earlier studies from west. - This increase in #Streptococcus abundance has also been observed in UC patients from different populations. [1.5] [#Parkinson’s Disease] [#Escherichia coli] [#Alpha-synuclein] - Among the 38 proneurodegenerative E. coli genes identified in the genome-wide screen, we previously characterized the genes responsible for producing the bacterial #Amyloid fibril #Curli, which could enter the host neurons to cross-seed the aggregation of α-syn and promote neurodegeneration. [1.6] [#Schizophrenia] - #Paraprevotella and #Catabacter were identified to have a strong correlation with the above four SCZ genesReferences Notes[ ]
