Paenibacillaceae ⇒ Paenibacillus {10001171}
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| Definition: | Paenibacillus |
| Initialisation date: | [ ] |
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| Rank: | Genus |
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| Domain: | Bacteria |
| Zone: | [ ] |
| Enzyme: | [ ] |
| Function: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- gut microbe–derived metabolite trimethylamine N-oxide (#TMAO), enhanced antitumor immunity to Pancreatic ductal adenocarcinoma (PDAC) - Delivery of #TMAO intraperitoneally or via a dietary choline supplement to orthotopic PDAC-bearing mice reduced tumor growth, associated with an immunostimulatory tumor-associated macrophage (TAM) phenotype, and activated effector T cell response in the tumor microenvironment. - #TMAO potentiated the type I interferon (IFN) pathway and conferred antitumor effects in a type I IFN–dependent manner. - bacteria producing an enzyme that generates #TMA was associated with positive immunotherapy outcomes in people with #Pancreatic Cancer. - #Bacillus and Paenibacillus species, were present at higher levels in people who survived for a long period of time after #Pancreatic Cancer. - [1.2]
- Other important #Firmicutes genera are #Listeria, Paenibacillus, #Staphylococcus, #Streptococcus, #Pediococcus, and #Leuconostoc.
References Notes
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