Listeriaceae ⇒ Listeria {10000777}
| Parent: | |
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| Definition: | Listeria |
| Initialisation date: | [ ] |
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| Rank: | Genus |
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| Domain: | Bacteria |
| Zone: | [ ] |
| Enzyme: | [ ] |
| Function: | [ ] |
Notes:
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Shared Reference Notes
- [1.1]
- Listeria spp. target tumors through the intracellular infection of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), which migrate to the immunosuppressive TME. - The transported Listeria is then transmitted from MDSCs to #Cancer cells via a unique cell–cell spread mechanism. - The shrinkage of tumors by Listeria spp. involves the combination of the direct killing of #Cancer cells by Listeria infection and cytotoxic T cell response toward Listeria antigens. - Listeria spp. convert a subpopulation of Listeria-infected MDSCs into an immune-stimulating phenotype that produces interleukin-12 (IL-12), a cytokine linked with heightened T cell and NK cell responses. - Listeria spp. directly kill #Cancer cells by activating NADP (+) oxidase and increasing intracellular calcium levels, which trigger the production of reactive oxygen species (ROS)
References Notes
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