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Listeria ⇒ Listeriaceae {10000777}

Record Keys


Organism:
Listeria
Parent:

Details


Initialisation date:[  ]

Meta Information


Rank:
 Genus
Domain:
 Bacteria
Zone:[  ]
Enzyme:[  ]
Function:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.3
    - Listeria spp. target tumors through the intracellular infection of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), which migrate to the immunosuppressive TME. - The transported Listeria is then transmitted from MDSCs to #Cancer cells via a unique cell–cell spread mechanism. - The shrinkage of tumors by Listeria spp. involves the combination of the direct killing of #Cancer cells by Listeria infection and cytotoxic T cell response toward Listeria antigens. - Listeria spp. convert a subpopulation of Listeria-infected MDSCs into an immune-stimulating phenotype that produces interleukin-12 (IL-12), a cytokine linked with heightened T cell and NK cell responses. - Listeria spp. directly kill #Cancer cells by activating NADP (+) oxidase and increasing intracellular calcium levels, which trigger the production of reactive oxygen species (ROS)

Common References