Disease ⇒ Autoimmune disease {40000524}

References Notes

Shared Reference Notes

• [1.1] 
  - Odoribacter and Mogibacteriaceae as the most important features with reduced abundance in autoimmune disease samples compared with healthy controls and Clostridium having increased expression in diseased participants
• [1.2] [#Western-style diet] 
• [1.3] [#Enterococcus gallinarum] 
  - E. gallinarum diverges into independent lineages adapted to colonize either luminal or mucosal niches in the gut. Compared with ancestral and luminal E. gallinarum, mucosally adapted strains evade detection and clearance by the immune system, exhibit increased translocation to and survival within the mesenteric lymph nodes and liver, and induce increased intestinal and hepatic inflammation. - Over time, E. gallinarum diverged into two distinct populations: one that behaved like the ancestral strain and another that gained the ability to escape the intestine and persist in the liver. - the population of E. gallinarum that translocated to the mice’s liver was able to temporarily evade detection and clearance by the mice’s immune system. - population that translocated to the liver triggered inflammation and exacerbated symptoms of autoimmune conditions.