Lactoferrin {90000136} Record Keys Parent:[ ] Definition:Lactoferrin Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Immun regulator, Anti-inflammatory, Anti-bacterial, Anti-cancer, Antioxidant, Enhancing Gut integrity Notes: [ ]Shared Reference Notes [1.1] - LF promotes the growth of low iron requiring bacteria thought to be beneficial to humans such as Lactobacillus and Bifidobacterium. - LF has direct fungicidal interaction against fungal cell surface that is not dependent on iron. - Lactoferrin exhibit immunomodulatory properties. [1.2] - LF > iron donor to support the growth of some bacteria with lower iron demands > #Lactobacillus sp. or #Bifidobacterium sp. - LF > binding with free iron >The lack of iron in Gut > suppresses the growth of #Escherichia coli (E. coli.), an iron-dependent bacteria [#Inflamatory bowel disease] - Lactoferrin > potent anti-inflammatory and immunomodulatory substrate > prevention and treatment of IBD through regulating intestine mucosal immune response. - Lactoferrin (LF), an iron-binding glycoprotein belonging to transferrin family, is a dietary bioactive component abundantly found in mammalian milk. - LF > perform diverse biological functions including antibacterial activity, anti-inflammatory activity, intestinal barrier protection, and immune cell modulation, and is involved in maintaining intestine mucosal immune homeostasis. - LF treatment > reduced the secretion and gene expression of tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8), interleukin-6 (IL-6), and nuclear factor-κB (NF-κB), and signal transducer and activator of transcription 3 (STAT3) signaling pathway activation. [1.3] [#Human milk oligosaccharides] [#Human breast milk] - Breast milk contains important developmental and immune-promoting factors such as oligosaccharides, immunoglobulins (IgA), and lactoferrin which protect the newborn passively and actively against excessive intestinal inflammation [1.4] - lactoferrin > suppresses biofilm formation by stimulating twitching, a specialized form of surface motility [1.5] - supplementation of #Lysozyme and lactoferrin to #Children aged 12–23 months in rural Malawi resulted in improved gut health as determined by their ingested #lactulose excreted into the urine, along with decreased rates of hospitalizationReferences Notes[ ]
