Disease ⇒ Rheumatic Hearth Disease {40000131}

Record Keys


Type:
Disease
Parent:[  ]
Definition:
Rheumatic Hearth Disease

Details


Initialisation date:
2021-03-10
Other Terms:[  ]

Meta Information


MedDra ID:[  ]
MedDra Level:[  ]
ICD:[  ]
Category:
Cardiovascular, Immunology
Zone:[  ]
Mechanism:[  ]

Notes:


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Shared Reference Notes


  • [1.1
    - The patients possessed higher levels of genera including Bifidobacterium and Eubacterium, and lower levels of genera including Lachnospira, Bacteroides, and Faecalibacterium. Coprococcus was identified as a super-generalist in fecal samples of the patients. Significant alterations were also observed in microbiota of subgingival plaques and saliva of the patients compared to control subjects.
  • [1.2] [#Atherosclerosis] [#Porphyromonas gingivalis
    - Oral microbes, including P. gingivalis, #Actinomyces, #Streptococcus, and #Treponema denticola, have been confirmed as sources of infected heart valves, atherosclerotic plaques, and rheumatic heart valves
  • [1.3] [#Hearth attack
    - Sodium #Butyrate, a metabolite of the gut microbiota, inhibited the activation of the NLRP3/Caspase-1 pyroptosis pathway in TGFβ1-induced Cardiac fibroblasts, repressed the transdifferentiation of Cardiac fibroblasts into myofibroblasts.

References Notes


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Common References


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