Disease ⇒ Rheumatic Hearth Disease {40000131}

Record Keys

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Rheumatic Hearth Disease


Initialisation date:
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Meta Information

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Cardiovascular, Immunology
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Shared Reference Notes

  • [1.1
    - The patients possessed higher levels of genera including Bifidobacterium and Eubacterium, and lower levels of genera including Lachnospira, Bacteroides, and Faecalibacterium. Coprococcus was identified as a super-generalist in fecal samples of the patients. Significant alterations were also observed in microbiota of subgingival plaques and saliva of the patients compared to control subjects.
  • [1.2] [#Atherosclerosis] [#Porphyromonas gingivalis
    - Oral microbes, including P. gingivalis, #Actinomyces, #Streptococcus, and #Treponema denticola, have been confirmed as sources of infected heart valves, atherosclerotic plaques, and rheumatic heart valves
  • [1.3] [#Hearth attack
    - Sodium #Butyrate, a metabolite of the gut microbiota, inhibited the activation of the NLRP3/Caspase-1 pyroptosis pathway in TGFβ1-induced Cardiac fibroblasts, repressed the transdifferentiation of Cardiac fibroblasts into myofibroblasts.

References Notes

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Common References

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