Lipocalin-2 {90000390} Record Keys Parent:[ ] Definition:Lipocalin-2 Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Pro-inflammatory Notes: [ ]Shared Reference Notes [1.1] [#Multiple Sclerosis] - bacteria thought to be beneficial for inflammatory bowel disease (IBD) such as #Anaerobutyricum, #Blautia, and #Roseburia, were reduced in fecal Lcn-2-high MS patients. [#Multiple Sclerosis] - decreasing trend in serum #Acetate (a short-chain fatty acid) levels in MS Lcn-2-high patients compared to healthy donors (HDs). - a decrease in the relative abundance of #Blautia massiliensis was significantly associated with a reduction of #Acetate in the serum of MS patients. [#Multiple Sclerosis] - fecal Lipocalin-2 (Lcn-2), a biomarker of intestinal inflammation, was significantly elevated and predominantly produced by the gut-infiltrating neutrophils. - The elevation of fecal Lcn-2 levels correlated with reduced bacterial diversity and increased levels of other intestinal inflammation markers including neutrophil elastase and #Calprotectin. References Notes[ ]
