Disease ⇒ Blood Brain Barrier Integrity {40000610}
Type: | Disease |
---|---|
Parent: | [ ] |
Definition: | Blood Brain Barrier Integrity |
Initialisation date: | [ ] |
---|---|
Other Terms: | [ ] |
MedDra ID: | [ ] |
---|---|
MedDra Level: | [ ] |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
[ ]
Shared Reference Notes
- [1.1]
- Trimethylamine, a metabolite of dietary #Choline, #Betaine, and l-#Carnitine, has been reported to exert detrimental impact on the BBB integrity. - - sodium #Butyrate administration exhibited an alleviating effect on BBB integrity.
- - #Deoxycholic acid and #Ursodeoxycholic acid, may also modulate BBB integrity.
- - #Propionic acid > promote BBB integrity by mitigating oxidative and proinflammatory pathways.
- - physiologically appropriate doses of the oxidized form of trimethylamine, #TMAO, improved the BBB integrity.
- [1.2] [#Short Chain Fatty Acid]
- Some SCFAs such as #Butyrate, #Propionate and #Acetate can cross the BBB probably through the monocarboxylate transport system generating a feedback inhibition on brain uptake. - [1.3] [#Alzheimer’s disease]
- Pericyte degeneration leads to BBB breakdown causing brain accumulation of blood-derived neurotoxic molecules. - Pericyte ischemic injury results in contractile rigor and obstruction of capillary blood flow. - Pericyte-specific genetic defects lead to primary familial brain calcification or Fahr’s disease. - Pericytes degenerate and likely play a role in cerebrovascular dysfunction in complex neurological diseases such as AD - [1.4]
- #Tryptophan can cross the BBB and affect #Serotonin synthesis in CNS - [1.5]
- #Ginger and its bioactive components have been shown to penetrate the blood-brain barrier via passive diffusion, suggesting the positive effects of #Ginger in CNS - [1.6]
- #Glyphosate can potentially expose humans through several routes, including skin contact, inhalation, and ingestion of contaminated food and water - #Glyphosate has the ability to cross the blood-brain barrier (BBB). - #Glyphosate can cause neurotoxic effects in animal models. - #Glyphosate exposure has also been associated with behavioral changes in rodents, such as decreased locomotion, increased anxiety levels, depression-like behavior, and impaired learning and memory processes - [1.7] [#Parkinson’s Disease] [#Alpha-synuclein]
- low concentration of #Mannitol inhibited the formation of fibrils, high concentration significantly decreased the formation of tetramers and high molecular weight oligomers and shifted the secondary structure of α-synuclein from α-helical to a different structure - [1.8]
- Bacterial EVs have been described with capability to cross the blood-brain barrier
References Notes
[ ]