Aspartic proteinases {90000655} Record Keys Parent:[ ] Definition:Aspartic proteinases Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Alzheimer’s disease, #Blood Brain Barrier Integrity] [#Candida albicans] [#Amyloid-beta] - C. albicans enters the mouse brain from the blood and induces two neuroimmune sensing mechanisms involving secreted aspartic proteinases (Saps) and #Candidalysin. - Saps disrupt tight junction proteins of the blood-brain barrier (BBB) to permit fungal brain invasion. - Saps also hydrolyze amyloid precursor protein (APP) into amyloid b (Ab)-like peptides that bind to Toll-like receptor 4 (TLR4) and promote fungal killing in vitro while #Candidalysin engages the integrin CD11b (Mac-1) on microglia.References Notes[ ]
