Dipeptidyl peptidase 4 {90000660} Record Keys Parent:[ ] Definition:Dipeptidyl peptidase 4 Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Diabetes Type 2] [#High Fat Diet] - microbial DPP4 was mainly produced by #Bacteroides spp. - Gut microbial DPP4 (mDPP4) could degrade active #GLP-1(7-37) in vitro. - mDPP4 could not affect active #GLP-1 levels in chow-fed mice but could decrease active #GLP-1 activity and impair #Glucose homeostasis in high-fat diet (HFD)–fed mice or dextran #Sulfate sodium/indomethacin–treated mice, suggesting that a damaged gut barrier is required for mDPP4 to affect the activity of host #GLP-1. - Gut microbial DPP4 isozyme can impair host #Glucose homeostasis, and variations in microbial DPP4 activities could possibly contribute to the heterogeneous responses to sitagliptin observed among patients with T2D.References Notes[ ]
