IL-1b {90000558} Record Keys Parent:[ ] Definition:IL-1b Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:Pro-inflammatory Notes: [ ]Shared Reference Notes [1.1] [#Otitis Media] [#Candida albicans] [#TNF-alfa] - introducing C. albicans into the guts of mice, a greater degree of ear swelling occurred accompanied by higher levels of proinflammatory cytokines (IL-1β, #IL-6 and TNF-α) in the ear [1.2] [#TNF-alfa] - anti-inflammatory cytokines (IL-4 and #IL-10) and proinflammatory cytokines (TNF-a, IL-1b, #IL-2, #IL-6, #IL-8, #IL-12, #IL-17, and #IL-18) are significantly changed by #Lactobacillus rhamnosus GG (LGG) [1.3] [#Cancer] - IL-1β was linked to lower expression of #E-cadherin, which promotes cell migration - Low #E-cadherin expression is correlated with disorders of cellular functions, growth inhibition, apoptosis, cell cycle arrest, and differentiation. It leads to aggressive carcinoma, higher invasiveness, and low patient survival [#Cancer] - In tissues of the periodontium, monocytes/macrophages, neutrophils, fibroblasts, and mast cells are the primary sources of IL-1β. - these cells synthesize IL-1β in response to activation from the influence of #Lipopolysaccharide (LPS), the main component of Gram-negative bacteria cell walls. - IL-1β causes osteoclast formation and bone resorption, which leads to local inflammatory changes in the periodontium. - IL-1β activates endothelial cells to produce vascular endothelial growth factor (VEGF) and other proangiogenic factors (e.g., TNF) which provide an inflammatory microenvironment for angiogenesis and tumor progression. - High IL-1β content is associated with tumor invasiveness, migration, and more aggressive tumor phenotype. [#Lipopolysaccharide, #TNF-alfa] - #Fusobacterium nucleatum LPS-activated inflammatory cytokines are include IL-1β, #IL-6, and TNF-α. The chronic inflammatory process leads to the loss of periodontal attachment and tissue damage [#TNF-alfa] - Periodontal pathogens affect growth of local concentrations of various cytokines including interleukin-1β (IL-1β), #IL-6, #IL-17, #IL-23, tumor necrosis factor-α (TNF-α), and matrix metalloproteinases MMP-8 and MMP-9References Notes[ ]
