O-Glycans {90000114}
Parent: | [ ] |
---|---|
Definition: | O-Glycans |
Queue: | [ ] |
Initialisation date: | 2020-11-05 |
---|---|
Specification: | |
[ ] | |
Source: | |
[ ] |
Structural Type: | [ ] |
---|---|
Functional Type: | [ ] |
Function: | Anti-inflammatory |
Notes:
- Colon mucus consists of two distinct O-glycosylated entities of Muc2: a major form produced by the proximal colon, which encapsulates the fecal material including the microbiota, and a minor form derived from the distal colon, which adheres to the major form. The microbiota directs its own encapsulation by inducing Muc2 production from proximal colon goblet cells. In turn, O-glycans on proximal colon-derived Muc2 modulate the structure and function of the microbiota as well as transcription in the colon mucosa.
Shared Reference Notes
- [1.1] [#Candida albicans]
- Mucus, specifically mucin O-glycans, suppresses adhesion and filamentation by c. albicans - [1.2]
- #Akkermansia muciniphila (A. muciniphila) and #Bacteroides thetaiotaomicron (B. theta), have glycoproteases that can degrade the protein core of the mucin domains with shortened O-glycans, but it remains unclear if any of these proteases can cleave intact MUC2. - - A major component of mucus is MUC2, a glycoprotein that is extensively decorated, especially with O-glycans. - Mucins are decorated with complex O-glycans that protect this glycoprotein from being easily degraded. - pathogens can be described as true mucin degraders due their ability to break down the mucin polymeric network causing the collapse of the mucus structure to allow bacterial tissue invasion. - commensal bacteria have evolved to utilize mucins by degrading O-glycans without disrupting the inner mucus layer barrier.
- [1.3]
- Core 3-derived O-glycans play an important role in the protective functions of mucus in the proximal colon where they are more highly expressed
References Notes
- (1) [1.4]