Caenorhabditis ⇒ Caenorhabditis elegans {10000299} Record Keys Parent:Caenorhabditis Definition:Caenorhabditis elegans Details Initialisation date:2020-10-13 Meta Information Rank: Species Domain:Worms Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Colonization of the C. elegans gut with enteric bacterial pathogens disrupted proteostasis in the intestine, muscle, neurons, and the gonad, while the presence of bacteria that conditionally synthesize butyrate, a molecule previously shown to be beneficial in neurodegenerative disease models, suppressed aggregation and the associated proteotoxicity. - Co-colonization with this butyrogenic strain suppressed bacteria-induced protein aggregation, [1.2] [#Parkinson’s Disease] [1.3] [#Alzheimer’s disease] [#Prevotella corporis, #Prevotella disiens] - specific species (p. disiens and p. corporis) decrease toxic polyglutamine (polyQ) aggregation in Caenorhabditis elegans [1.4] - #Vitamin B12-producing bacteria that colonize the intestine can modulate excitatory cholinergic signalling and behaviour in the host Caenorhabditis elegans. - #Vitamin B12 reduces cholinergic signalling in the nervous system through rewiring of the #Methionine (Met)/#S-adenosylmethionine cycle in the intestine. [1.5] - #Trigonelline incorporates into the NAD+ pool and increases NAD+ levels in Caenorhabditis elegans, mice and primary myotubes from healthy individuals and individuals with #Sarcopenia.References Notes (1) [1.6]
