Glycine {60000093} Record Keys Parent:[ ] Definition:Glycine Queue:[ ] Details Initialisation date:2020-10-06 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - #Cocaine raises gut norepinephrine levels facilitating #Proteobacteria colonization. - #Proteobacteria colonization depletes glycine in gut, blood, and CSF in mice. - Glycine depletion alters #Cocaine-induced neuroplasticity and drug responses. [1.2] [#Clostridium difficile associated disease] [#Clostridioides difficile] [#Bile Acids] - #Taurine conjugates inhibit growth less, while glycine conjugates and deconjugated BAs are much more toxic to C. difficile. [#Bile Acids] - #Lactobacillaceae BSHs display a clear bias for either glycine or #Taurine-conjugated BAs. [1.3] [#Diabetes Type 1] [#Bile Acids, #Deoxycholic acid] - stool concentrations of secondary BAs, particularly UDCA, DCA, HDCA, and their glycine and/or #Taurine conjugates, were downregulated in P2Ab versus P1Ab and/or CTR groups. [1.4] - Following #Walnut Diet > greater K00613 gene expression by #Gordonibacter > encodes glycine amidinotransferase (GATM). - GATM is involved in #Arginine and glycine metabolism and catalyzes the transfer of the guanidino group from l-#Arginine to glycine or l-lysine producing guanidinoacetate or l-homoarginine, respectively. - GATM deficiency results in diminished intracellular energy stores and a lack of l-#Homoarginine and has been linked to impaired cardiac and cerebrovascular function. [1.5] [#Secondary bile acids] - BAs serve as signaling molecules with the ability to bind to receptors such as farnesoid X receptor (FXR), Takeda G protein-coupled receptor 5 (TGR5), constitutive androstane receptor (CAR), and more. - Each BA is able to bind with multiple receptor types with varying degrees of effec.t. - #Bile Acids can be conjugated with glycine, #Taurine, and to a lesser studied extent, other amino acids, which can affect the ability of BAs to act as substrates for specific receptors in the body. [1.6] [#Diabetes Type 2] [#Ruminococcus gnavus] - R. gnavus was found to have a positive correlation with glycine #Ursodeoxycholic acid (GUDCA) levels, which have been shown to improve metabolism by promoting fat thermogenesis [1.7] [#Alzheimer’s disease] - AD patients > DCA and its conjugated forms with glycine and #Taurine increased, and #Deoxycholic acid was associated with decreased cognitive abilitiesReferences Notes[ ]
