Homoarginine {90000671} Record Keys Parent:[ ] Definition:Homoarginine Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - the vascular benefits of homoarginine are at least partially attributable to increased #Nitric Oxide production, a potent vasodilator. Homoarginine is a substrate for endothelial #Nitric Oxide synthase (eNOS), which catalyzes the conversion of l-#Arginine to #Nitric Oxide. - homoarginine may inhibit #Arginine catabolism by arginase therefore increasing l-#Arginine availability for #Nitric Oxide production [#Atherosclerosis] [#Glycine amidinotransferase] [#Walnut] - GATM gene correlate with plasma homoarginine concentrations and greater cellular GATM expression in vitro is associated with increased homoarginine. - Low serum homoarginine is an independent biomarker for increased risk of adverse cardiovascular events and all-cause mortality. - homoarginine supplementation reduces atherosclerotic plaque development via modulation of the adaptive immune system - Following #Walnut Diet > greater K00613 gene expression by #Gordonibacter > encodes #Glycine amidinotransferase (GATM). - GATM is involved in #Arginine and #Glycine metabolism and catalyzes the transfer of the guanidino group from l-#Arginine to #Glycine or l-lysine producing guanidinoacetate or l-homoarginine, respectively. - GATM deficiency results in diminished intracellular energy stores and a lack of l-homoarginine and has been linked to impaired cardiac and cerebrovascular function.References Notes[ ]
