Chlamydia pneumoniae {50002152} Record Keys Parent:[ ] Definition:Chlamydia pneumoniae Details Initialisation date:[ ] Meta Information Rank: Species Domain: Bacteria Zone:[ ] Enzyme:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - C. pneumoniae is unique among several microbes that have been associated with arterial disease in having been demonstrated with frequency in atherosclerotic lesions but not in normal arterial tissue. - The organism was found not only in coronary arteries but also in carotid, aortic, femoral and popliteal arteries. [1.2] [#Alzheimer’s disease] - Among different types of microbes, #Human immunodeficiency virus-1 (HIV-1), #Herpes simplex virus-1 (HSV-1), Chlamydia pneumonia, #Spirochetes and #Candida albicans are frequently detected in the brain of AD patients. - #Amyloid-beta protein has demonstrated to exhibit antimicrobial properties upon encountering these pathogens. [1.3] - #Alzheimer’s disease brains tissue > presence of #HSV1, #Borrelia burgdorferi, and Chlamydia pneumoniae in AD brains. [1.4] [#Amyloid-beta] - Chlamydia pneumoniae can infect the olfactory and trigeminal nerves, olfactory bulb and brain within 72 h in mice. - Chlamydia pneumoniae infection also resulted in dysregulation of key pathways involved in #Alzheimer’s disease pathogenesis at 7 and 28 days after inoculation. - Amyloid beta accumulations were also detected adjacent to the Chlamydia pneumoniae inclusions in the olfactory system. - Injury to the nasal epithelium resulted in increased peripheral nerve and olfactory bulb infection, but did not alter general CNS infection.References Notes[ ]
