Oral administration of Inulin Gel {51111231} Record Keys Definition:Oral administration of Inulin Gel Queue:[ ] Details Initialisation date:2021-09-09 Specification: [ ] Meta Information Type:Prebiotic Host: Mouse Zone:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Cancer] - In multiple murine tumour models, #Inulin—a widely consumed dietary fibre—formulated as a ‘colon-retentive’ orally administered gel can effectively modulate the gut microbiome in situ, induce systemic memory-T-cell responses and amplify the antitumour activity of the checkpoint inhibitor anti-programmed cell death protein-1 (α-PD-1). - Orally delivered #Inulin-gel treatments increased the relative abundances of key commensal microorganisms and their short-chain-fatty-acid metabolites, and led to enhanced recall responses for interferon-γ+CD8+ T cells as well as to the establishment of stem-like T-cell factor-1+PD-1+CD8+ T cells within the tumour microenvironment. References Notes[ ]
