Disease ⇒ Thrombotic events {40000154} Record Keys Type:Disease Parent:[ ] Definition:Thrombotic events Details Initialisation date:2021-05-21 Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - #TMAO was found to contribute to thrombotic events by causing platelet hyperactivity [1.2] - #TMAO has a direct effect on platelets, increasing platelet reactivity and thrombosis through altered intracellular calcium signals elicited by a variety of agonists. [1.3] [#Acylcarnitines] [#Antibiotic Therapy] - #2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in patients with #Covid-19 and in patients with major adverse cardiovascular events (MACEs). - 2MBC enhances platelet hyperreactivity and thrombus formation in mice. - 2MBC binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. - Genetic depletion or pharmacological inhibition of integrin α2β1 largely reverses the pro-thrombotic effects of 2MBC. - 2MBC can be generated in a gut-microbiota-dependent manner, whereas the accumulation of plasma 2MBC and its thrombosis-aggravating effect are largely ameliorated following antibiotic-induced microbial depletion. References Notes[ ]
