Disease ⇒ Selective immunoglobin A (IgA) deficiency {40000620}

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Selective immunoglobin A (IgA) deficiency


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Shared Reference Notes

  • [1.1
    - In IgA-deficiency > translocation of specific bacterial taxa associated with elevated levels of systemic IgG targeting fecal microbiota. - Associated features of immune system dysregulation in IgA-deficient mice and humans included elevated levels of inflammatory cytokines, enhanced follicular CD4 T helper cell frequency and activation, and an altered CD8 T cell activation state. - In children and adolescents who lack both systemic and fecal IgA, bacteria were more likely to breach the gut barrier and travel to lymph nodes in the abdomen.

References Notes

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Common References

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