Lactobacillus ⇒ Limosilactobacillus (Lactobacillus) reuteri {10000141}

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Limosilactobacillus (Lactobacillus) reuteri


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- Lactobacillus reuteri lives naturally in the gastrointestinal tract of many animals and healthy people, but it is not found in every individual.
- It colonizes the digestive tract in the first few hours of life, as it is also found in breast milk. If the mother ingests more L. reuteri, more can be found in the breast milk, which simplifies the rapid colonization. This is particularly helpful with diarrhea and colic in children and possibly with necrotizing enterocolitis in premature babies.
- Oral ingestion also has a preventive effect against intestinal diseases, but the concentration decreases as soon as the ingestion is stopped.
- Stress, inflammation, and prolonged use of antibiotics can also lead to a decrease. However, the bacterium can be found in many foods, especially fermented products, dairy products and meat.
- In the oral microbiome, clinical studies have shown reduced numbers of Streptococcus mutans when the oral cavity was colonized by L. reuteri. S. mutans is involved in the development of tooth decay.
- L. reuteri also protects the gums from inflammation and reduces the build-up of plaque.
- In order to provide this important immune support, it produces antimicrobial substances such as Reuterin, which is also effective against a Candida fungal attack, among other things.
- For “good” microbes to be affected, the concentration of Reuterin must be five times higher than for “bad” microbes.
With such a player, the lactobacillus genus has truly earned the title of Microbe of the Year 2018

- Lactobacillus reuteri
- Prevents Dental Plaque and Carries.
- Improves Neonethal Colics.
- Produces anti microbial metabolites.

- Produces a metabolite that activates the vagus nerve to promote oxytocin, the cuddle hormone.This hormone then turns
on the brain reward center for social behavior. Impeding the message at any point along this relay from bacteria to
metabolite to vagus nerve to oxytocin receptors impairs the animals sociability.

Shared Reference Notes

  • [1.1] [#Oxytosin
    - L. reuteri. send signals along vagus gut-brain connection. - The vagus nerve connects to a brain region called the hypothalamus, which produces the hormone oxytocin. - Feeding mice with L. reuteri increases oxytocin in the blood. - L. reuteri normalizes brain oxytocin levels in the SHANK3 mice. It also boosts the strength of their neuronal connections. - The bacterial treatment does not work if the mice lack oxytocin receptors in reward neurons or if they first get a drug that blocks oxytocin receptors.
  • [1.2] [#Autism
    - Treatment with L. reuteri selectively rescues social deficits in genetic, environmental, and idiopathic ASD models. - The effects of L. reuteri on social behavior are not mediated by restoring the composition of the host gut microbiome, which is altered in all of these ASD models. - L. reuteri acts in a vagus nerve-dependent manner and rescues social interaction-induced synaptic plasticity in the ventral tegmental area of ASD mice, but not in oxytocin receptor-deficient mice
  • [1.3] [#Autism
    - Host genetics and microbiota differentially regulate behaviors in an ASD mouse model - Microbe therapy (L. reuteri) rescues social deficits in ASD mouse model but not hyperactivity - Microbe-induced metabolite tetrahydrobiopterin (BH4) selectively rescues social deficits in ASD mouse model - L. reuteri and tetrahydrobiopterin (BH4) improves in ASD mouse model social-reward-mediated synaptic transmission
  • [1.4] [#Depression] [#Lactobacillaceae] [#Probiotic (Bifidobacter and Lactobacilus)
    - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and #Anxiety symptoms at four weeks. > improvement in #Sleep quality. - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels. - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > increased #Bifidobacteriaceae and Lactobacillacea, whereas it decreased #Enterobacteriaceae in the gut microbiota composition.
  • [1.5] [#Short Chain Fatty Acid] [#High Fat Diet
    - maternal high-fat diet (MHFD) in mice induces gut dysbiosis, social dysfunction, and underlying synaptic plasticity deficits in male offspring. - Post-weaning Limosilactobacillus reuteri treatment increases the abundance of short-chain fatty acid-producing taxa and rescues MHFD-descendant social deficits.
  • [1.6] [#Condition of chronic stress
    - chronic stress was connected with increased #Depression-like behavior (as measured by the forced swim test), reduced Lactobacillus spp. in the fecal microbiome, as well as increased circulating levels of #kynurenine, a direct metabolite of #Tryptophan via the enzyme IDO1. - supplemented the diet of the mice with L. reuteri ATCC 23272 for an additional 4 weeks, which was sufficient to reverse behavior and #kynurenine concentrations. - The reversal of #Depression-like behaviors was diminished if #kynurenine levels were artificially elevated during probiotic supplementation, suggesting a link between #kynurenine signaling and #Depression-like behavior.
  • [1.7] [#Increased oxytocin
    - the probiotic Limosilactobacillus reuteri (formerly known as Lactobacillus reuteri) has been shown to not only increase circulating Oxt levels but also Oxt expression in the brain in rodents
  • [1.8] [#UV radiation
    - #Lactic acid secreted by Lactobacillus reuteri DSM 17,938 can protect skin from UVB by suppressing pro-inflammatory #IL-6 and IL-8 cytokines.
  • [1.9] [#Klebsiella pneumoniae] [#Short Chain Fatty Acid
    - In the K. pneumoniae infection mice model, gut microbial composition (down-regulates Lactobacillus reuteri and #Bifidobacterium pseudolongum) and cecal metabolome (SCFAs) are altered
  • [#Indole-3-aldehyde] - #Probiotic Lactobacillus reuteri (Lr) translocates to, colonizes, and persists within #Melanoma, where via its released dietary #Tryptophan catabolite I3A, it locally promotes interferon-γ-producing CD8 T cells, thereby bolstering ICI (immune checkpoint inhibitor ).
  • [1.11
    - probiotics (e.g., Lactobacillus reuteri) might increase the systemic #Vitamin D level.
  • [1.12
    - #Resistant Starch tightened the gut epithelial barrier and reduced the translocation of L. reuteri
  • [#Systemic lupus erythematosus] - SLE > abundance of Lactobacill. reuteri increased in TLR7.1 Tg mice and Lactobacill. reuteri colonization exacerbated systemic autoimmunity under specific-pathogen-free and gnotobiotic conditions.
  • [1.13] [#Clostridioides difficile, #Lactobacillus bulgaricus, #Lactobacillus delbrueckii
    - There are several bacteria that can produce #Folate in the gut, which include #Bacteroides fragilis, #Prevotella copri, #Clostridium difficile, #Lactobacillus plantarum, L. reuteri, L. delbrueckii ssp. bulgaricus, #Streptococcus thermophilus, #Bifidobacterium spp. (some species), #Fusobacterium varium, and #Salmonella enterica
  • [1.14
    - Lactobacillus reuteri, producing the #AHR ligand indole-3-aldehyde (IAld)
  • [1.15] [#Indole-3-acetaldehyde
    - Lactobacillus reuteri is known to be a common gut-dwelling strain that possesses the ability to produce (IAld) in the I3AA-dependet pathway. - This synthesis of IAld by L. reuteri results in #AHR-dependent #IL-22 production and gut protection from inflammation, indicating IAld as a beneficial bacterial-derived metabolite.
  • [1.16] [#Depression] [#Bifidobacterium breve] [#Human breast milk
    - #Probiotic L. reuteri PBS072 and B. breve BB077 > at days 45 and 90, significantly ameliorated the mothers’ mood, the breastfeeding quality and improved the baby’s cries.
  • [1.17
    - Lactobacillus reuteri was found to increase the serum #Vitamin D level. - #Vitamin D plays a role in suppressing renin-angiotensin-aldosterone activity, improving function of vascular wall and alleviating vascular #Oxidative stress to regulate #Hypertension
  • [1.18] [#Gastric carcinoma, #Peptic ulcer] [#Bifidobacterium adolescentis, #Bifidobacterium bifidum, #Bifidobacterium breve, #Bifidobacterium longum, #Bifidobacterium pseudocatenulatum, #Chloracidobacterium thermophilum B, #Helicobacter pylori
    - H. pylori infection alone is not sufficient to develop severe gastric abnormalities such as gastric cancer and gastric ulcers. - A lower abundance of gut resident #Bifidobacterium genus with specific strains ( B. adolescentis, B. bifidum, B. breve, B. longum, B. moukalabense, B. pseudocatenulatum, and B. reuteri.) plays a significant role in developing severe gastric malignancy.
  • [1.19
    - treating mice with #Lactobacilli strains known to produce #AHR ligands such as Lactobacillus reuteri, led to increased #AHR activity in the small intestine and ameliorated intestinal inflammation
  • - #Catechins prevented gut ecological dysregulation in rats by modulating the PPARγ/CD36 pathway and promoting the growth of healthy microorganisms, such as #Akkermansia muciniphila and Lactobacillus reuteri
  • [1.21] [#Osteoporosis] [#Probiotic
    - L. reuteri > Could reduce bone loss associated with estrogen deficiency in an ovariectomized (Ovx) mouse menopausal model. - Osteoclast bone resorption markers and activators (Trap5 and RANKL) as well as osteoclastogenesis are significantly decreased in L. reuteri-treated mice. - L. reuteri treatment may be a straightforward and cost-effective approach to reduce post-menopausal bone loss.

References Notes

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Common References

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