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- Listeria spp. target tumors through the intracellular infection of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), which migrate to the immunosuppressive TME.
- The transported Listeria is then transmitted from MDSCs to cancer cells via a unique cell–cell spread mechanism.
- The shrinkage of tumors by Listeria spp. involves the combination of the direct killing of cancer cells by Listeria infection and cytotoxic T cell response toward Listeria antigens.
- Listeria spp. convert a subpopulation of Listeria-infected MDSCs into an immune-stimulating phenotype that produces interleukin-12 (IL-12), a cytokine linked with heightened T cell and NK cell responses.
- Listeria spp. directly kill cancer cells by activating NADP (+) oxidase and increasing intracellular calcium levels, which trigger the production of reactive oxygen species (ROS)
- [1.1] Dysbiosis of fecal microbiota in Crohn's Disease patients as revealed by a custom phylogenetic microarray   [Inflammatory Bowel Diseases] [Journal]
- [1.2] Microbiome of the placenta in pre-eclampsia supports the role of bacteria in the multifactorial cause of pre-eclampsia   [The journal of obstetrics and gynaecology research] [Journal]
- [1.3] Tweak to Treat: Reprograming Bacteria for Cancer Treatment  [Review]  [Trends in Cancer] [Journal]