MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in
≡ List 

Listeria {10000777}

Record Keys
Organism:
Listeria
Class:[  ]

Details
Initialisation date:[  ]

Meta Information
Taxonomy:[  ]
Domain:[  ]
Zone:[  ]
Enzyme:[  ]
Function:[  ]

Notes

[  ]

Shared Notes

  • [1.3] 
    - Listeria spp. target tumors through the intracellular infection of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), which migrate to the immunosuppressive TME.
    - The transported Listeria is then transmitted from MDSCs to cancer cells via a unique cell–cell spread mechanism.
    - The shrinkage of tumors by Listeria spp. involves the combination of the direct killing of cancer cells by Listeria infection and cytotoxic T cell response toward Listeria antigens.
    - Listeria spp. convert a subpopulation of Listeria-infected MDSCs into an immune-stimulating phenotype that produces interleukin-12 (IL-12), a cytokine linked with heightened T cell and NK cell responses.
    - Listeria spp. directly kill cancer cells by activating NADP (+) oxidase and increasing intracellular calcium levels, which trigger the production of reactive oxygen species (ROS)

Common References