Microbiome & Chronic Diseases

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Listeria {10000777}

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Shared Notes

  • [1.3
    - Listeria spp. target tumors through the intracellular infection of tumor-infiltrating myeloid-derived suppressor cells (MDSCs), which migrate to the immunosuppressive TME.
    - The transported Listeria is then transmitted from MDSCs to cancer cells via a unique cell–cell spread mechanism.
    - The shrinkage of tumors by Listeria spp. involves the combination of the direct killing of cancer cells by Listeria infection and cytotoxic T cell response toward Listeria antigens.
    - Listeria spp. convert a subpopulation of Listeria-infected MDSCs into an immune-stimulating phenotype that produces interleukin-12 (IL-12), a cytokine linked with heightened T cell and NK cell responses.
    - Listeria spp. directly kill cancer cells by activating NADP (+) oxidase and increasing intracellular calcium levels, which trigger the production of reactive oxygen species (ROS)

Common References