MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Akkermansia {10000161}

Record Keys


Organism:
Akkermansia
Parent:[  ]

Details


Authoring date:
2019-05-05

Links


Meta Information


Taxonomy:
Genus
Domain:
Bacteria
Zone:[  ]
Enzyme:[  ]
Function:
Mucin-degrading, Anti-inflammatory

Notes


[  ]

Shared Notes


  • [1.58
    -Increased abundance of Akkermansia and Holdemania were found to be predictive of MS.
    - Akkermansia showed negative associations with the bile acid components taurocholate, bile acid glycocholate and fatty acid anions 3-hydroxyoctanoate and caproate.
    - The identification of bile acids associated with a number of our taxa is consistent with several studies showing an integral role of the gut bile acid pool as a modulator of host immune response and inflammation
  • [1.59
    - Akkermansia spp can reduce inflammation by a number of different mechanisms such as reducing plasma level of lipopolysaccharide (LPS)-binding protein (LBP), reducing the expression of inflammatory genes, and reducing the production of pro-inflammatory cytokines such as IL-17, IL-23, IL-8, TNF-α as well as increasing the production of anti-inflammatory cytokines such as IL-10 and IL-12.
    - While low levels of Akkermansia were found in obesity and type-2 diabetes mouse models, exogenous administration of Akkermansia increased the control of gut inflammation and permeability by regulating tight-junction-related proteins, and thickening the intestinal mucous layer.
  • - The commonly used diabetes treatment Metformin increase Akkermansia spp. abundance, and to significantly improve glucose metabolism in high-fat diet fed mice while also increasing the number of mucin-producing goblet cells.
  • - The population of Akkermansia in the gut is negatively modulated by the fat content of the consumed diet.

Common References