Salmonella typhimurium ⇒ Salmonella {10000155}
| Organism: | Salmonella typhimurium |
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| Parent: |
| Authoring date: | 2020-09-06 |
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| Taxonomy: | Species |
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| Domain: | Bacteria |
| Zone: | [ ] |
| Enzyme: | [ ] |
| Function: | [ ] |
Notes
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Shared Notes
- [1.1]
- S. typhimurium, an intracellular pathogen, is chemoattracted to, and retained in, tumors due to the presence of metabolites produced by quiescent cancer cells within the TME (Tumor Micro envirounment).
- Once in the tumor, S. typhimurium continues to proliferate and directly kills cancer cells by triggering of apoptosis, necrosis, and cell rupture.
- S. typhimurium flagellin has been found to mount the antitumor response of CD8+ T and Natural Killer (NK) cells and to reduce the frequency of regulatory T cells (Tregs)
Common References
- [1.1] Tweak to Treat: Reprograming Bacteria for Cancer Treatment [2021] [Review] [80001782] [Trends in Cancer] [Journal]