Microbiome & Chronic Diseases

Evidence Based Medicine

Akkermansia muciniphila ⇒ Akkermansia {10000154}

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Akkermansia muciniphila


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-The colon has two distinct mucus structures: the outer layer is colonized by mucin-degrading bacteria and is characterized by the presence of Bacteroides acidifaciens, Bacteroides fragilis, Bifidobacteriaceae and Akkermansia muciniphila and the inner layer and crypts are penetrated at low density by a more restricted community that includes Bacteroides fragilis and Acinetobacter spp. (2)

- Akkermansia muciniphila is a mucin degraders, an important role in the preservation of the integrity of the gut mucus layer, thus limiting the risk of systemic inflammation

Shared Notes

  • [1.34
    - For instance, gram negative bacteria as Proteobacteria and Akkermansia muciniphila (Verrucomicrobia), which use mucus as a carbon and Nitrogen source, adhere and reside within the mucus layer.
  • [1.6
    - A. muciniphila exerts its beneficial effects on metabolism independently from generalized changes in the plasmatic eCBome mediators in the context of the metabolic syndrome.
    - Oral supplementation with the alive bacterium significantly prevented the reduction of 2-PG and 1-PG levels observed upon the progression of the metabolic syndrome.
  • [1.35
    - The gut bacterium Akkermansia muciniphila is associated with protection from obesity, enhanced wound healing, and augmented antitumor responses.
    - This microbe induces antigen-specific immunoglobulin G1 (IgG1) antibodies generated by B cells with CD4+ T cell help.
    - This is in contrast to most anticommensal responses, which involve the T cell–independent production of IgA antibodies.
    - In a gnotobiotic setting in which all components of the microbiome are defined, A. muciniphila–specific T cells expanded only when A. muciniphila was present.

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