Microbiome & Chronic Diseases

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Lactobacillus reuteri ⇒ Lactobacillus {10000141}

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Lactobacillus reuteri


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Gut Lumen
Enzyme:[  ]
Function:[  ]


- Lactobacillus reuteri lives naturally in the gastrointestinal tract of many animals and healthy people, but it is not found in every individual.
- It colonizes the digestive tract in the first few hours of life, as it is also found in breast milk. If the mother ingests more L. reuteri, more can be found in the breast milk, which simplifies the rapid colonization. This is particularly helpful with diarrhea and colic in children and possibly with necrotizing enterocolitis in premature babies.
- Oral ingestion also has a preventive effect against intestinal diseases, but the concentration decreases as soon as the ingestion is stopped.
- Stress, inflammation, and prolonged use of antibiotics can also lead to a decrease. However, the bacterium can be found in many foods, especially fermented products, dairy products and meat.
- In the oral microbiome, clinical studies have shown reduced numbers of Streptococcus mutans when the oral cavity was colonized by L. reuteri. S. mutans is involved in the development of tooth decay.
- L. reuteri also protects the gums from inflammation and reduces the build-up of plaque.
- In order to provide this important immune support, it produces antimicrobial substances such as Reuterin, which is also effective against a Candida fungal attack, among other things.
- For “good” microbes to be affected, the concentration of Reuterin must be five times higher than for “bad” microbes.
With such a player, the lactobacillus genus has truly earned the title of Microbe of the Year 2018

- Lactobacillus reuteri
- Prevents Dental Plaque and Carries.
- Improves Neonethal Colics.
- Produces anti microbial metabolites.

- Produces a metabolite that activates the vagus nerve to promote oxytocin, the cuddle hormone.This hormone then turns
on the brain reward center for social behavior. Impeding the message at any point along this relay from bacteria to
metabolite to vagus nerve to oxytocin receptors impairs the animals sociability.

Shared Notes

  • [1.5
    - L. reuteri. send signals along vagus gut-brain connection.
    - The vagus nerve connects to a brain region called the hypothalamus, which produces the hormone oxytocin.
    - Feeding mice with L. reuteri increases oxytocin in the blood.
    - L. reuteri normalizes brain oxytocin levels in the SHANK3 mice. It also boosts the strength of their neuronal connections.
    - The bacterial treatment does not work if the mice lack oxytocin receptors in reward neurons or if they first get a drug that blocks oxytocin receptors.
  • [1.6
    - Treatment with L. reuteri selectively rescues social deficits in genetic, environmental, and idiopathic ASD models.
    - The effects of L. reuteri on social behavior are not mediated by restoring the composition of the host gut microbiome, which is altered in all of these ASD models.
    - L. reuteri acts in a vagus nerve-dependent manner and rescues social interaction-induced synaptic plasticity in the ventral tegmental area of ASD mice, but not in oxytocin receptor-deficient mice
  • [1.4
    - Host genetics and microbiota differentially regulate behaviors in an ASD mouse model
    - Microbe therapy (L. reuteri) rescues social deficits in ASD mouse model but not hyperactivity
    - Microbe-induced metabolite tetrahydrobiopterin (BH4) selectively rescues social deficits in ASD mouse model
    - L. reuteri and tetrahydrobiopterin (BH4) improves in ASD mouse model social-reward-mediated synaptic transmission

Common References