MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine

Bacteroides fragilis ⇒ Bacteroides {10000104}

Record Keys
Organism:
Bacteroides fragilis
Class:

Details
Initialisation date:
2019-05-14

Links

Meta Information
Taxonomy:
‎Species
Domain:
‎Bacteria
Zone:
‎Gut Inner Mucus
, 
‎Gut Outer Mucus
Enzyme:[  ]
Function:
Mucin-degrading, Cancerogenic

Notes

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Shared Notes

  • [1.33] 
    - The immunomodulatory molecule polysaccharide A derived from the human commensal Bacteroides fragilis mediates the conversion of CD4+ T cells into FOXP3+ Treg cells that produce IL-10 during commensal colonization, stimulating immunological development within mammalian hosts
  • [1.34] 
    - During colonization of animals with the ubiquitous gut microorganism Bacteroides fragilis, a bacterial polysaccharide (PSA) directs the cellular and physical maturation of the developing immune system, correcting systemic T cell deficiencies and TH1/TH2 imbalances and directing lymphoid organogenesis.
    - PSA presented by intestinal dendritic cells activates CD4+ T cells and elicits appropriate cytokine production.
  • [1.35] 
    - Addition of a single probiotic bacterial species, Bacteroides fragilis Depending on Polysaccharide A Expression, can ameliorate MS disease through immunomodulation .
  • [1.32] 
    - Bacteroides fragilis toxin (Bft), can indirectly damage the host DNA by eliciting high levels of reactive oxygen species (ROS)
  • [1.3] 
    - BF is enriched in patients with polyps > inflammatory cytokines in the mucosa adjacent to polyps.
    - BF from polyps is enriched for LPS biosynthesis genes, activates TLR4, and induces IL-12 > induce a pro-inflammatory response.
    - Presence of LPS genes and elevated expression of LPS are found in polyp tissues.
  • [1.36] 
    - The colon has two distinct mucus structures: the outer layer is colonized by mucin-degrading bacteria and is characterized by the presence of Bacteroides acidifaciens, Bacteroides fragilis, Bifidobacteriaceae and Akkermansia muciniphila and the inner layer and crypts are penetrated at low density by a more restricted community that includes Bacteroides fragilis and Acinetobacter spp.

Common References