test Bacteroides fragilis ⇒ Bacteroides | Microbiome | MetaBiom

Microbiome & Chronic Diseases

Evidence Based Medicine

Bacteroides fragilis ⇒ Bacteroides {10000104}

Record Keys
Organism:	Bacteroides fragilis
Parent:	Bacteroides

Details
Authoring date:	2019-05-14

Links
Source

Meta Information
Taxonomy:	‎Species
Domain:	‎Bacteria
Zone:	[ ]
Enzyme:	[ ]
Function:	[ ]

Notes

- The colon has two distinct mucus structures: the outer layer is colonized by mucin-degrading bacteria and is characterized by the presence of Bacteroides acidifaciens, Bacteroides fragilis, Bifidobacteriaceae and Akkermansia muciniphila and the inner layer and crypts are penetrated at low density by a more restricted community that includes Bacteroides fragilis and Acinetobacter spp. (1)

Shared Notes

[1.31]
- The immunomodulatory molecule polysaccharide A derived from the human commensal Bacteroides fragilis mediates the conversion of CD4+ T cells into FOXP3+ Treg cells that produce IL-10 during commensal colonization, stimulating immunological development within mammalian hosts
[1.32]
- During colonization of animals with the ubiquitous gut microorganism Bacteroides fragilis, a bacterial polysaccharide (PSA) directs the cellular and physical maturation of the developing immune system, correcting systemic T cell deficiencies and TH1/TH2 imbalances and directing lymphoid organogenesis.
- PSA presented by intestinal dendritic cells activates CD4+ T cells and elicits appropriate cytokine production.

Common References

[1.1] Temporal changes in gut microbiota profile in children with acute lymphoblastic leukemia prior to commencement-, during-, and post-cessation of chemotherapy [2020] [80001331] [BMC Cancer]
[1.2] Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified [2013] [80000449] [PLOS ONE]
[1.3] Potential of fecal microbiota for early-stage detection of colorectal cancer [2014] [80000814] [Molecular Systems Biology]
[1.4] Gut mucosal microbiome across stages of colorectal carcinogenesis [2015] [80000724] [Nature communications]
[1.5] Fecal microbiota in pediatric inflammatory bowel disease and its relation to inflammation [2015] [80000523] [The American Journal of Gastroenterology]
[1.6] Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease [2005] [80000610] [Journal of Clinical Microbiology]
[1.7] Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease [2020] [80001325] [Nature communications]
[1.8] Age and fecal microbial strain-specific differences in patients with spondyloarthritis [2018] [80000687] [Arthritis Research & Therapy]
[1.9] Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome_DUBLICATE [2018] [80000965] [Science translational medicine]
[1.10] Alterations in the gut bacterial microbiome in fungal keratitis patients [2018] [80000884] [PLOS ONE]
[1.11] Profiling the urinary microbiome in men with calcium-based kidney stones [2020] [80001327] [BMC Microbiology]
[1.12] Altered gut microbiome and metabolome in patients with multiple system atrophy [2018] [80000745] [Movement Disorders]
[1.13] Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients [2018] [80000825] [Scientific Reports]
[1.14] Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: a cross-sectional study [2018] [80000800] [Schizophrenia Research]
[1.15] Fecal microbiota composition differs between children with β-cell autoimmunity and those without. [2013] [80000603] [Diabetes]
[1.16] Gut microbiota dysbiosis in children with relapsing idiopathic nephrotic syndrome [2018] [80000692] [American Journal of Nephrology]
[1.17] Alterations of the gut microbiome and plasma proteome in Chinese patients with adolescent idiopathic scoliosis [2019] [80000917] [Bone]
[1.18] Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. [2017] [80000280] [Neurobiology of Aging]
[1.19] Microarray analysis reveals marked intestinal microbiota aberrancy in infants having eczema compared to healthy children in at-risk for atopic disease [2013] [80000476] [BioMed Central Microbiology]
[1.20] Gut microbiota dysbiosis is associated with altered bile acid metabolism in infantile cholestasis [2019] [80001288] [mSystems]
[1.21] Alteration of the gut microbiota in Chinese population with chronic kidney disease [2017] [80000616] [Scientific Reports]
[1.22] Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer [2013] [80000303] [Digestive Diseases and Sciences]
[1.23] Dysbiosis of fecal microbiota in Crohn's Disease patients as revealed by a custom phylogenetic microarray [2010] [80000285] [Inflammatory Bowel Diseases]
[1.24] Characterization of the circulating microbiome in acute-on-chronic liver failure associated with hepatitis B [2019] [80001046] [Liver International]
[1.25] Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. [2011] [80000294] [Gastroenterology]
[1.26] Changes of intestinal bacterial microbiota in coronary hearth disease complicated with nonalcoholic fatty liver disease [2019] [80001292] [BMC Genomics]
[1.27] Intestinal Dysbiosis and lowered Serum lipopolysaccharide-binding protein in Parkinson's Disease [2015] [80000278] [PLOS ONE]
[1.28] Fecal microbiota in early rheumatoid arthritis [2008] [80001229] [The Journal of Rheumatology]
[1.29] Toward defining the autoimmune microbiome for type 1 diabetes [2011] [80000310] [The ISME Journal]
[1.30] A single species of Clostridium subcluster XIVa decreased in ulcerative colitits patients [2016] [80000620] [Inflammatory Bowel Diseases]
[1.31] Connection between the Gut Microbiome, Systemic Inflammation, Gut Permeability and FOXP3 Expression in Patients with Primary Sjögren’s Syndrome [2020] [Research] [80001479] [International journal of molecular sciences]
[1.32] An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System [2005] [Research] [80001566] [Cell]

Increased abundance in Disease

‐ Acute lymphoblastic leukemia Anal swab ‎Human [1.1]
‐ Autism Faeces ‎Human [1.2]
‐ Autism ‎Ameliorative ‎Gut Lumen ‎Mouse
‐ Celiac disease ‎Causal ‎Gut Lumen ‎Human
‐ Colorectal cancer Faeces ‎Human [1.3]
‐ Colorectal cancer Tissue biopsie ‎Human [1.4]
‐ Colorectal cancer ‎Causal
‐ Crohn's disease Faeces ‎Human [1.5]
‐ Crohn's disease Tissue biopsie ‎Human [1.6, 1.7]
‐ Enthesitis-related arthritis Faeces ‎Human [1.8]
‐ Inflammatory bowel disease Faeces ‎Human [1.9]
‐ Keratitis Faeces ‎Human [1.10]
‐ Kidney stone Urine ‎Human [1.11]
‐ Multiple Sclerosis ‎Preventive
‐ Multiple system atrophy Faeces ‎Human [1.12]
‐ Osteoarthritis Synovial tissue ‎Human [1.13]
‐ Pervasive developmental disorder NOS Faeces ‎Human [1.2]
‐ Schizophrenia Faeces ‎Human [1.14]
‐ Type 1 diabetes Faeces ‎Human [1.15]
‐ Ulcerative Colitis Tissue biopsie ‎Human [1.6]
‐ Ulcerative Colitis Faeces ‎Human [1.16]

Decreased abundance in Disease

‐ Adolescent idiopathic scoliosis Faeces [1.17]
‐ Alzheimer's disease Faeces [1.18]
‐ Atopic eczema Faeces [1.19]
‐ Autism ‎Causal
‐ Cholestasis Faeces [1.20]
‐ Chronic kidney disease Faeces [1.21]
‐ Colorectal cancer Faeces [1.22]
‐ Colorectal cancer Tissue biopsie [1.3]
‐ Crohn's disease Faeces [1.16, 1.23, 1.23]
‐ Depression ‎Causal
‐ Diverticular disease Faeces [1.16]
‐ Hepatitis B associated liver failure Plasma [1.24]
‐ Irritable bowel syndrome Faeces [1.25]
‐ Non-alcoholic fatty liver disease Faeces [1.26]
‐ Parkinson's Disease Faeces [1.27]
‐ Rheumatoid Arthritis Faeces [1.28]
‐ Type 1 diabetes Faeces [1.29]
‐ Ulcerative Colitis Faeces [1.30]

Increased abundance by Factor

‐ Sugar intake

Siblings

‐ Bacteriodes uniformis [10000659]
‐ Bacteroides barnesiae [10002083]
‐ Bacteroides caccae [10000129]
‐ Bacteroides capillosus [10000807]
‐ Bacteroides cellulosilyticus [10001813]
‐ Bacteroides clarus [10001671]
‐ Bacteroides coprocola [10000531]
‐ Bacteroides coprophilus [10000296]
‐ Bacteroides dorei [10000221]
‐ Bacteroides eggerthii [10001096]
‐ Bacteroides faecis [10001647]
‐ Bacteroides finegoldii [10000801]
‐ Bacteroides fragilis group [10001201]
‐ Bacteroides intestinalis [10000566]
‐ Bacteroides massiliensis [10001111]
‐ Bacteroides nordii [10002038]
‐ Bacteroides ovatus [10000788]
‐ Bacteroides pectinophilus [10001228]
‐ Bacteroides plebeius [10000789]
‐ Bacteroides salyersiae [10001507]
‐ Bacteroides sartorii [10002103]
‐ Bacteroides stercoris [10000530]
‐ Bacteroides thetaiotaomicron [10000674]
‐ Bacteroides uniformis [10000181]
‐ Bacteroides ureolyticus [10000549]
‐ Bacteroides vulgatus [10000146]
‐ Bacteroides xylanisolvens [10000128]
‐ Bacteroides xylanolyticus [10001673]
‐ Bacteroides-Prevotella group [10000883]

Postbiotic

‐ Polysaccharide A
‐ Succinate

References

(1) The mucus layers of the small intestine and colon [2016]